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Research Journal of Pharmacognosy، جلد ۱۱، شماره ۴، صفحات ۳۹-۴۸
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عنوان انگلیسی Oleo-Gum-Resin of Ferula persica: Phytochemical Analysis and Enzyme Inhibitory Activity Related to Alzheimer’s Disease
چکیده انگلیسی مقاله Background and objectives: Medicinal plants have effectively treated Alzheimer’s disease (AD). In this study, the oleo-gum-resin of Ferula persica known as sagapenum was selected to investigate its inhibitory activity toward enzymes involved in the creation and progression of AD. Also, the phytochemical analysis, which was not previously reported in the literature, was conducted. Methods: The in vitro inhibitory activity of dichloromethane, methanol, and aqueous extracts was investigated toward acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) according to the modified Ellman’s method. Moreover, the phytochemical analysis of the most potent extract was conducted using different column chromatography techniques. Results: The dichloromethane extract showed selective BuChE inhibitory activity (IC50 = 23.41 µg/mL), compared with donepezil as the reference drug (IC50 = 1.97 µg/mL). Phytochemical analysis of the related extract led to the isolation and identification of aurapten, farnesiferol A, umbelliprenin, farnesiferol C, farnesiferone A, karatavicinol, ferocaulidin, and ligupersin A, which were assayed toward cholinesterases (ChEs). Farnesiferol A was the most potent and selective inhibitor of BuChE (IC50 = 31.46 µg/mL). Moreover, it showed good β-secretase 1 (BACE1) inhibitory activity (IC50 = 5.14 µM), compared with the positive control, OM99-2 (IC50 = 0.014 µM) to be considered a multi-target directed ligand against AD. Conclusions: Selective anti-BuChE activity of the dichloromethane extract of sagapenum, as well as farnesiferol A and its good anti-BACE1 activity, may play a significant role in the development of anti-AD supplements.  
کلیدواژه‌های انگلیسی مقاله Alzheimer’s disease,Ferula,oleo-gum-resin,phytochemicals
نویسندگان مقاله Shima Ghadami |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Mina Saeedi |
Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Reza Delnavazi |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Mahdieh Eftekhari |
Department of Pharmacognosy and Pharmaceutical Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Najmeh Edraki |
Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Tahmineh Akbarzadeh |
Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Mahnaz Khanavi Khanavi |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Reza Shams Ardekani |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

نشانی اینترنتی https://www.rjpharmacognosy.ir/article_203241_66492e18e4d42e47fe41cc46564e1b53.pdf
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