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Nanomedicine Journal، جلد ۴، شماره ۲، صفحات ۸۳-۸۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Preparation and evaluation of nanoparticles composed of thiolated methylated pyridinyl chitosan as a new strategy for bucal drug delivery of insulin
چکیده انگلیسی مقاله Objective(s): The purpose of this study is about the preparation and evaluation of nanoparticles composed of thiolated methylated pyridinyl chitosan (TMPC) which are made P.E.C method, for bucal drug delivery of insulin.Materials and Methods: First of all have to synthesize methylated pyridinyl chitosan and then for (TMPC) L-cysteine should be attached to methylated pyridinyl chitosan by the formation amid bounds. After of synthesis the (TMPC) nanoparticles were made and insulin loaded on them. The percentage of entrapment efficiency which was calculated for a nanoparticle which loaded by insulin is about to 91+2.6%.Results: The release of insulin from nanoparticles was studied in vitro in Phosphate buffer solution (PBS) pH 6.8. After 240 minutes 71.3% of insulin released from (TMPC) and after 360 minutes 72.9% of insulin was released. By considering the specifications of nanoparticles which leads us to this result that the Zeta potential is 28.3 mv, poly dispersity index (pdi) is 0.33 and the size of the particles is about to 268 nm.Conclusion: this study suggests that thiolated methylated pyridinyl chitosan can act as a potential enhancer for bucal delivery of insulin.
کلیدواژه‌های انگلیسی مقاله Bucal, Chitosan, Nanoparticles, Pyridinyl, Thiolated
نویسندگان مقاله بابک zolfagharnia | babak zolfagharnia
department of pharmaceutics, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

الهه مرتضویان | elaheh mortazavian
tehran darou pharmaceutical company, tehran, iran


داود کاویانی | davood kaviani
young researchers and elite club, east tehran branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مرتضی رفیعی تهرانی | morteza rafiee tehrani
tehran darou pharmaceutical company, tehran, iran
نشانی اینترنتی http://nmj.mums.ac.ir/article_8409.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/295/article-295-325967.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده مقاله پژوهشی
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