این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Addiction and Health، جلد ۱۶، شماره ۳، صفحات ۱۹۸-۲۰۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Potential Involvement of Apelin/APJ System in Addiction and Neuroprotection Against Drugs of Abuse
چکیده انگلیسی مقاله Addiction, characterized by compulsive drug-seeking behavior and impaired self-control, remains a significant public health 
concern. Understanding the neurobiology of addiction is crucial for identifying novel therapeutic targets and further developing 
effective treatments. Recently, the apelin/APJ system, an emerging signaling pathway, has attracted attention for its involvement 
in various neuropsychiatric disorders. The cross-talk between the apelin/APJ system and hypothalamic mu opioid signaling, as 
well as its heterodimerization with kappa opioid receptors (KORs), supports the potential relevance of this system to addiction. 
Moreover, several protective effects of apelin against various addictive substances, including methamphetamine, morphine, and 
alcohol, underscore the need for further investigation into its role in substance use disorder. Understanding the contribution 
of the apelin/APJ system in addiction may offer valuable insights into the underlying neurobiology and pave the way for 
novel therapeutic interventions in substance use disorders. This review provides a concise overview of the apelin/APJ system, 
emphasizing its physiological roles and highlighting its relevance to addiction research.
کلیدواژه‌های انگلیسی مقاله apelin, APJ, Addiction, substance use disorder, Drug abuse
نویسندگان مقاله Reza Saboori Amleshi |
Institute of Neuropharmacology, Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran

Masoud Soltaninejad |
Institute of Neuropharmacology, Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran

Mehran Ilaghi |
Institute of Neuropharmacology, Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran

نشانی اینترنتی https://ahj.kmu.ac.ir/article_92486_12ab14be22075d72ac4053c6034bddbd.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات