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Journal of Medicinal Plants and By-products، جلد ۱۳، شماره ۳، صفحات ۶۸۰-۶۹۰
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عنوان انگلیسی Evaluation of the Anti-inflammatory and Immunomodulatory Properties of Jatropha multifida stem sap
چکیده انگلیسی مقاله Inflammatory diseases remain a significant public health issue, posing challenges in their management due to the adverse effects associated with conventional anti-inflammatory drugs. Exploring medicinal plants as a viable avenue for researching novel anti-inflammatory drugs offers a promising alternative. Jatropha multifida is a well-known traditional plant of the Euphorbiaceae family with undisputed medicinal properties, both haemostatic and antimicrobial. Very little data exists on its anti-inflammatory properties. This study aimed to assess the anti-inflammatory and immunomodulatory properties of Jatropha multifida stem sap
The anti-inflammatory activity of the stem sap was evaluated in vitro by the anti-hemolytic activity assessment method, in vivo by the paw edema test in rats. The immunomodulatory potential was determined using a chemical mediator of inflammation, TNFα. Its antioxidant activity by the DPPH method was evaluated.
The results of this study revealed that Jatropha multifida sap with an LC50 of 0.604 mg/mL, is non-toxic and showed a 66.21% higher anti-hemolytic effect than Diclofenac (25.94 %) and Ibuprofen (40 %). It also has a high DPPH inhibitory power (86.61 %) at 0.5 mg/mL similar to that of vitamin C. Sap at the concentration of 800 mg/Kg has overall the same effects on paw inflammation as Diclofenac and results in a greater decrease in TNFα (286.15) at values similar to those of normal control rats.
The therapeutic use of this sap in a traditional setting is therefore once again justified due to its proven anti-inflammatory and immunomodulatory properties.
کلیدواژه‌های انگلیسی مقاله Jatropha multifida, Anti-inflammatory, rat, Tnfα
نویسندگان مقاله Lauris Fah |
Research Unit in Applied Microbiology and Pharmacology of natural substances, Polytechnic school of Abomey-Calavi, University of Abomey-Calavi

Jean Robert Klotoé |
Research Unit in Applied Microbiology and Pharmacology of natural substances, Polytechnic school of Abomey-Calavi, University of Abomey-Calavi

Eric Agbodjento |
Research Unit in Applied Microbiology and Pharmacology of natural substances, Polytechnic school of Abomey-Calavi, University of Abomey-Calavi

Victorien Tamègnon Dougnon |
Research Unit in Applied Microbiology and Pharmacology of natural substances, Polytechnic school of Abomey-Calavi, University of Abomey-Calavi

Alice Kitchey |
Research Unit in Applied Microbiology and Pharmacology of natural substances, Polytechnic school of Abomey-Calavi, University of Abomey-Calavi

Kévin Sintondji |
Research Unit in Applied Microbiology and Pharmacology of natural substances, Polytechnic school of Abomey-Calavi, University of Abomey-Calavi

Esther Déguénon |
Research Unit in Applied Microbiology and Pharmacology of natural substances, Polytechnic school of Abomey-Calavi, University of Abomey-Calavi

Jean Marc Atègbo |
Faculty of Science and Technology, University of Abomey-Calavi

نشانی اینترنتی https://jmpb.areeo.ac.ir/article_131573_94e5ba2dbe0a10d43bccfd1064bcf818.pdf
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