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Iranian Journal of Toxicology، جلد ۱۱، شماره ۳، صفحات ۱۱-۱۸
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عنوان انگلیسی Comparative Effect of Silymarin and D-Penicillamine on Lead Induced Hemotoxicity and Oxidative Stress in Rat
چکیده انگلیسی مقاله Background: This study was performed to investigate the adverse effects of acute lead intoxication on hemogram, erythrocyte osmotic fragility and oxidant/antioxidant status and the probable ameliorating effect of silymarin in comparison to d-penicillamine. Methods: Forty-eight albino rats were divided in 8 groups and received the following treatments in a 10 day experiment in Shahid Chamran University of Ahvaz, southwest Iran in 2015. Group 1: Normal saline as control; Group 2: 25 mg/kg lead acetate, intraperitoneally (IP) for the last 5 days; Group 3: 100 mg/kg D-penicillamine, IP for the last 5 days; Group 4: 200 mg/kg silymarin, orally for 10 days; Group 5, 6, 7 and 8: In addition to lead, they received D-penicillamine, for the last 5 days, silymarin for 10 days, a combination of silymarin for 10 days and D-penicillamine for the last 5 days, and silymarin for the last 5 days, respectively. Results: Lead exposure induced a significant microcytic anemia accompanied by a significant elevation in total leukocyte, lymphocyte and neutrophil counts. Erythrocyte superoxide dismutase (SOD) and glutathion peroxidase (Gpx) activities were significantly increased along with a significant elevation of malondialdehyde (MDA) concentration in lead treated rats. Activities of SOD and Gpx were significantly alleviated by silymarin administration for 10 days while both D-penicillamine and silymarin could significantly reduce MDA concentration. Conclusion: Acute lead exposure induced significant leukocytosis and anemia that was associated with increased activity of erythrocyte antioxidant enzymes and lipid peroxidation. Silymarin in contrast to D-penicillamine treatment was more effective in preventing lead-induced oxidative stress in erythrocytes.
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نویسندگان مقاله سیده میثاق جلالی | seyedeh missagh jalali
department of clinical sciences, shahid chamran university of ahvaz, ahvaz, iran.

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

حسین نجف زاده | hossein najafzadeh
department of basic sciences, shahid chamran university of ahvaz, ahvaz, iran.

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

سیده مریم موسوی | seyedeh maryam mousavi
doctor of veterinary medicine, shahid chamran university of ahvaz, ahvaz, iran.

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-422-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/138/article-138-326796.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده پژوهشی
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