این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Medical Physics، جلد ۱۴، شماره ۱، صفحات ۵۳-۵۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Radio-Protective Effects of N-Acetylcysteine on Radiation-Induced Lethality in Mice
چکیده انگلیسی مقاله Introduction It has long been known that ionizing radiation can lead to detrimental effects in normal cells. In this light, Radioprotective chemicals have been used to decrease morbidity or mortality caused by ionizing irradiation. This study aimed to evaluate the radio-protective effect of N-acetylcysteineagainst radiation-induced mortality in male mice. Materials and Methods 52 healthy male mice were divided into four groups including NAC before irradiation (1), irradiation (2), NAC after irradiation (3) NAC before irradiation (4) and control. Three groups were treated orally with 100 mg/ kg of NAC. Gamma irradiation was performed at 8 Gy using a Co-60 machine. Kaplan-Meier method and the log-rank test were performed, using SPSS version 16. The significance level was considered to be 0.05. Results The statistical analysis revealed a significant difference between the test and control groups (P>0.05). The percentage of survival after 30 days was 46.2% for the irradiation group (1). In addition, the percentage of decreased lifespan was calculated at 5.90%, 23.60% and 17.93% for the first-third groups, respectively. Conclusion Results revealed lack of effectiveness of treatment with NAC after lethal dose. These results suggested that application of NAC for mice before irradiation protected them from the lethal effects of whole-body irradiation.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله اشکان سلاجقه | ashkan salajegheh
department of radiology, school of paramedical sciences, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مهدی حسینی | mehdi hoseini
medical physics department, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مینا نوری | mina nouri
department of radiology, school of paramedical sciences, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

رسول دهقانی سلطانی | rasool dehghani soltani
student research committee, kerman university of medical sciences, kerman- iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

یاسر معصومی اردکانی | yaser masoumi ardakani
physiology research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://ijmp.mums.ac.ir/article_8464.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/145/article-145-326809.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Paper
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