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Medical Laboratory Journal، جلد ۱۰، شماره ۵، صفحات ۱-۱۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Role of Homocysteine in Diseases: A Review
چکیده انگلیسی مقاله ABSTRACT Cardiovascular disease (CVD) is one of the most important causes of mortality worldwide. Several risk factors have been proposed to be associated with CVD. The main risk factors include family history, smoking, hypertension, history of diabetes, hyperlipidemia and obesity. However, new factors have been recently proposed to be associated with CVD. These include blood homocysteine, fibrinogen, plasma factor VII activity, lipoprotein (a) and several other factors. Nowadays, the role of homocysteine in the development and exacerbation of several diseases has been demonstrated. Extensive studies have been performed on the role of homocysteine in diabetes, preeclampsia, depression, Alzheimer's disease and multiple sclerosis. Homocysteine level increases with age. Moreover, absorption of micronutrients, especially vitamin B12, decreases in old age that could cause a further increase in homocysteine level. On the other hand, elasticity of blood vessels decline with aging, and increased levels of homocysteine accelerate atherosclerosis. The sum of these processes highlights the role of homocysteine in the development and exacerbation of several diseases. Keywords: Homocysteine, Cardiovascular Disease, Diabetes, Preeclampsia, Depression, Alzheimer's Disease.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله مریم مرادی بیناباج | maryam moradi binabaj
biochemistry of nutrition research center, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حمیدرضا جوشقانی | hamidreza joshaghani
department of medical laboratory, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

مژگان نجابت | mojgan nejabat
department of medicinal chemistry, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://goums.ac.ir/mljgoums/browse.php?a_code=A-10-1-418&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/168/article-168-326924.pdf
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زبان مقاله منتشر شده en
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