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Physiology and Pharmacology، جلد ۲۸، شماره ۳، صفحات ۲۸۲-۲۹۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Omega-3 PUFAs counteracts high fructose diet-induced gonadal impairment via fortified antioxidant defense
چکیده انگلیسی مقاله Introduction: The consumption of fructose sweeteners as an alternative to high-calorie diets has been linked to various metabolic diseases due to increased oxidative stress. This study investigated changes in testicular and ovarian functions following Omega-3 polyunsaturated fatty acid supplementation (ω-3 PUFAs) in rats fed a High Fructose Diet (HFD). Methods: Forty Wistar rats were equally and randomly distributed into four groups. Each group was further subdivided by gender, with an equal number of animals in each sub-group. Group A assigned as control, while Groups B and C were administered HFD containing 10% and 20% v/v fructose solution, respectively. Group D rats were provided 20% v/v HFD and ω-3 PUFAs. Results: After six weeks of consumption, HFD resulted in reduced semen quality and gonadal reproductive hormone levels, while increasing testicular and ovarian oxidative stress. ω-3 PUFAs improved semen quality, reproductive hormone concentrations, and antioxidant defense system. Conclusion: HFD impairs gonadal function, however, dietary supplementation with ω-3 PUFAs improves gonadal functions by enhancing the antioxidant defense mechanism.
کلیدواژه‌های انگلیسی مقاله High-fructose diet,Infertility,Omega-3,Ovary,Oxidative stress
نویسندگان مقاله | Ehitare Ekhoye
Department of Physiology, Edo State University Uzairue


| Ejime Agbonifo-Chijiokwu
Department of Physiology, Delta State University


| Eze Nwangwa
Department of Physiology, Delta State University
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1724-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Endocrine Physiology/Pharmacology
نوع مقاله منتشر شده Experimental research article
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