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عنوان انگلیسی An Overview of Three-Dimensional Culture Systems for Recapitulation Human Organs in Research: Advances and Applications
چکیده انگلیسی مقاله Cell culture is a vital method in biological and biomedical research. The global cell culture market, valued at around USD 26.54 billion in 2023, is projected to surpass USD 63.60 billion by 2032. While two-dimensional cell culture has led to significant advancements in biology, its simplicity does not accurately reflect the complex in vivo environment. This can result in misleading data with limited predictive value for in vivo applications, prompting increased interest in three-dimensional (3D) cultivation methods. The 3D cell culture mimics the behavior and organization of cells in vivo by emulating the extracellular matrix (ECM), providing better insights into 3D interactions among cells and between cells and the matrix, thus reconstructing their natural microenvironment. In this review we will outline the various types of 3D models (include spheroids, organoids, bio-printed structures, and tissue chips). Subsequently, we will examine the methodologies employed to develop 3D culture systems (include four category methods). Lastly, the practical applications and challenges of these 3D models will be addressed. The future research will likely concentrate on incorporating cutting-edge technologies to improve the reproducibility and applicability of 3D models in research.
 
کلیدواژه‌های انگلیسی مقاله Cell culture,3D models,Spheroid,Organoid,Matrix-based structures,Microfluidic system,Personalized medicine,Cancer research
نویسندگان مقاله | Nahid Moradi
Applied Cell Sciences Division, Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| Sadaf Vahdat
Applied Cell Sciences Division, Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
نشانی اینترنتی http://mjms.modares.ac.ir/browse.php?a_code=A-10-85104-1&slc_lang=en&sid=30
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