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Middle East Journal of Cancer، جلد ۱۵، شماره ۴، صفحات ۲۷۲-۲۸۰
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عنوان انگلیسی The Clinical Utility of Biochemical Biomarkers in Colorectal Cancer
چکیده انگلیسی مقاله Colorectal cancer (CRC) ranks as the third most prevalent cancer worldwide and is a leading cause of cancer-related mortality. Since many colon cancers present no significant clinical symptoms, identifying new biomarkers or a set of biological indicators significant for clinical trials is crucial for the early detection of CRC. This advancement also aids in establishing new objectives for interventional therapeutic strategies against the disease. Currently, research is exploring various proteins, glycoproteins, and cellular and humoral substances involved in cellular homeostasis mechanisms as potential cancer markers. This review examines the potential utility of fucosylation and sialylation processes, as well as sex hormones, as biomarkers in the diagnosis and prognosis of CRC. A comprehensive search was conducted in PUBMED, MEDLINE, and Google Scholar, supplemented by a manual search of relevant journals. The keywords were L-fucose, sialic acid, fucosyltransferase-4, galectin-3, and steroid hormones in CRCs.
کلیدواژه‌های انگلیسی مقاله Glycoproteins,Fucosyltransferase,Galectin,L-fucose,Sialic acid
نویسندگان مقاله Durdi Qujeq |
Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

Roya Abbasi Natajomrani |
Department of Food and Drug Deputy, Mazandaran University of Medical Sciences, Sari, Iran

Reza Hajihosseini |
Department of Biochemistry, Payame Noor University, Tehran, Iran

Vahid Hosseini |
Non-communicable Diseases Institute, Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Arash Kazemi Veisari |
Non-communicable Diseases Institute, Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Khadijeh Hoznian |
Imam Khomeini Educational Hospital, Mazandaran University of Medical Sciences, Sari, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_49875_4eee0e1019e9e3b2507e6f5dfe5c7fde.pdf
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