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Physiology and Pharmacology، جلد ۲۱، شماره ۱، صفحات ۱۵-۲۴
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Ursolic acid: a versatile triterpenoid compound in regulating the aging
چکیده انگلیسی مقاله We and other studies have elucidated single molecules that can attenuate aging and extend longevity. Indeed, these molecules could prevent age-associated diseases simultaneously and probably extending healthy-life spans. In this review, we discuss recent advances, controversies, opportunities and challenges surrounding ursolic acid (UA) in relationship with aging. In this regard, UA also known as urson, prunol, micromerol and malol is a pentacyclic triterpenoid compound which naturally occurs in a large number of vegetarian foods, medicinal herbs and other plants, including apples and rosemary. Our previous studies for the first time evaluated anti-aging effects of UA. These studies indicated that UA through overexpression of anti-aging biomarkers such as sirtuin (SIRT) 1, SIRT6 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha/beta (PGC-1α/β). Klotho and orexin-A in the brain, skeletal muscle, liver and kidney ameliorates aging and thereby conferring broad health benefits in rodents, primates and possibly human. Taken together, our recent findings advantageously described that UA mimics short-term caloric restriction, exercise and has a potential therapy for age-related diseases. Finally, the prospects for drugs that can deliver at least a subset of the benefits of caloric restriction seems very real.
کلیدواژه‌های انگلیسی مقاله Ursolic Acid, aging, Sirtuins, PGC-1β/α, Klotho.
نویسندگان مقاله نورالدین بختیاری | nuredin bakhtiari
department of biochemistry, faculty of basic sciences, sanandaj branch, islamic azad university, sanandaj, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

الهام moslemee جلالوند | elham moslemee jalalvand


jahanfard کاظمی | jahanfard kazemi


نشانی اینترنتی http://phypha.ir/ppj/browse.php?a_code=A-11-792-4&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/26/article-26-327723.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cellular and Molecular BioMedicine
نوع مقاله منتشر شده Review article (by invitation)
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