این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۲۱، شماره ۱، صفحات ۲۵-۳۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Hyperprolactinemia and CYP2D6, DRD2 and HTR2C genes polymorphism in patients with schizophrenia
چکیده انگلیسی مقاله Introduction: Hyperprolactinemia is a common serious side effect of antipsychotic medications that are currently used in the treatment of patients with schizophrenia. Pharmacogenetic approaches offer the possibility of identifying patient-specific biomarkers for predicting the risk of this side effect. We investigated a possible relationship between variants (SNPs) in genes for cytochrome 2D6 (CYP2D6), dopamine-2 receptor (DRD2) and serotonin-2C receptor (HTR2C) and antipsychotic drug-induced hyperprolactinemia in patients with schizophrenia. Methods: Overall, 128 Russian patients with paranoid schizophrenia (61F/67M, aged 18-65 y) were included. Serum prolactin concentration was measured with ELISA. DNA analysis and genotyping of CYP2D6 (rs3892097), DRD2 (rs6275) and HTR2C (rs6318) genes was done with StepOnePlus Real-Time PCR System using TaqMan® SNP Genotyping Assays (Applied Biosystems, USA). Results: Our study showed an association of the CYP2D6 (rs3892097) and HTR2C (rs6318) gene polymorphism with hyperprolactinemia in patients with schizophrenia on the background of therapy. No associations were identified between the DRD2 (rs6275) gene polymorphism and the risk of antipsychotic-induced hyperprolactinemia in patients with schizophrenia. Conclusion: Our study confirms a contribution of genetic factors to the antipsychotic-induced hyperprolactinemia in patients with schizophrenia. Further studies are required to unravel the genetic predictors of antipsychotic-induced side effects and to develop the personalized treatment strategies for patients with schizophrenia.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله اولگا yu fedorenko | olga yu fedorenko
mental health research institute, tomsk nrmc, russia


anton j m loonen | anton j m loonen
department of pharmacy, university of groningen, groningen, the netherlands


natalya m vyalova | natalya m vyalova
mental health research institute, tomsk nrmc, russia


аnastasiya s boiko | аnastasiya s boiko
mental health research institute, tomsk nrmc, russia


ایوان v pozhidaev | ivan v pozhidaev
mental health research institute, tomsk nrmc, russia


دیانا z osmanova | diana z osmanova
mental health research institute, tomsk nrmc, russia


lyubov d rakhmazova | lyubov d rakhmazova
mental health research institute, tomsk nrmc, russia


nikolay а bokhan | nikolay а bokhan
mental health research institute, tomsk nrmc, russia


mikhail v ivanov | mikhail v ivanov
bekhterev psychoneurological research institute, st. petersburg, russia


maxim b freidin | maxim b freidin
department of twin research and genetic epidemiology, king amp;apos;s college london, london, united kingdom


سوتلانا а ivanova | svetlana а ivanova
mental health research institute, tomsk nrmc, russia
نشانی اینترنتی http://phypha.ir/ppj/browse.php?a_code=A-10-942-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/26/article-26-327724.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات