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Physiology and Pharmacology، جلد ۲۱، شماره ۱، صفحات ۷۲-۷۹
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عنوان انگلیسی Melatonin effects on the melanophores in adults and tadpoles of Rana cyanophlyctis (Schneider)
چکیده انگلیسی مقاله Introduction: Effects of melatonin (MT) were comparatively examined on melanophores of isolated skin in adults and tadpole’s tailfin of a frog Rana cyanophlyctis. MT is generally considered as a potent melanophores aggregating hormone besides regulating the sleep wake cycle in vertebrates. Methods: Melanophore size index (MSI) was chosen as a recording parameter of the responses. Concentration-response curve was obtained by application of MT to the frog skin. Against this MT, antagonists were employed to observe their blocking effects on aggregatory responses of frog melanophores. Results: MT has induced aggregation in a wide dose-range on spotted and non-spotted regions in adults as well as in the tailfin of tadpoles. MT induced aggregation was somewhat independent to the applied concentrations of MT and beyond the dose 4.31 × 10-8 M of MT, aggregation of melanophores was decreased. Phenomenons of auto-desensitization and auto-antagonism have been observed. For tadpoles, the sensitivity to MT was higher than that of the adult skin melanophores as evident with the lowest threshold dose of MT to induce a discernible response. MT induced aggregatory responses were effectively inhibited by the specific MT antagonists luzindole and K-185 and also by the Ca++ channel blocker verapamil. Seasonal variation in inhibition of MT receptors by K-185 is being reported in this species. Conclusion: Tadpole melanophores of Rana cyanophlyctis were more sensitive towards MT aggregation than their adult counterparts. Seasonal variations and auto-desensitization are all expressed through the specific MT1, MT2 receptors and Ca++ channels.
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نویسندگان مقاله عرفان احمد شیخ | irfan ahmed sheikh
department of biosciences, barkatullah university, bhopal mp - 462 026 , india


محمد mubashshir | muhammad mubashshir
department of medical lab amp;amp; tech., al-falah university, faridabad haryana - 121 004 , india


safia sumoona | safia sumoona
department of biosciences, barkatullah university, bhopal mp - 462 026 , india


محمد اویس | mohd ovais
department of biosciences, barkatullah university, bhopal mp - 462 026 , india
نشانی اینترنتی http://phypha.ir/ppj/browse.php?a_code=A-10-394-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/26/article-26-327729.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Others
نوع مقاله منتشر شده Original Research
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