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Physiology and Pharmacology، جلد ۲۰، شماره ۴، صفحات ۲۷۷-۲۸۶
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی The effects of moderate treadmill and running wheel exercises on oxidative stress in female rats with steroid-induced polycystic ovaries
چکیده انگلیسی مقاله Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrinological pathologies in women during their reproductive years with ovulatory dysfunction, abdominal obesity, hyperandrogenism and insulin resistance. The aim of the present research was to evaluate the total antioxidant capacity (TAC), total oxidant status (TOS), free testosterone, ovarian morphology and estrous cyclicity in the estradiol valerate (EV)-induced PCOS rat model and the effect of treadmill and running wheel exercises on these parameters. Methods: Fifty female Wistar rats were randomly selected (220 ± 20 g). They had every 2 to 3 consecutive estrous cycles during 12 to 14 days. The first two groups were divided into control (n=10) and polycystic (n=40) that were induced PCOS by EV injection after 60 days. The polycystic groups were divided into three groups (n=10 in each group) PCOS, experiment group with treadmill exercise (running for 28 m/min at 60 min/day) and experiment group with running wheel exercise (running daily for 4 hours) for 8 weeks. Results: The PCOS rats had significantly higher testosterone, TOS and lower TAC than control. Eight weeks of treadmill and running wheel exercise significantly increased serum levels of TAC (just for treadmill exercise) and decreased level of TOS and T (just for treadmill exercise) in EV-induced PCOS rats compared to PCOS group. Ovarian morphology and estrous cycle was almost normalized in the PCOS exercise (treadmill and running wheel) groups. Conclusion: The present study demonstrate EV-induced PCOS in rats is associated with an increased oxidative stress and this increase can be returned to normal levels by exercise.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله فاطمه آقایی | fatemeh aghaie
department of physiology, faculty of biological sciences, shahid beheshti university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

همایون خزعلی | homayoun khazali
department of physiology, faculty of biological sciences, shahid beheshti university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

مهدی هدایتی | mehdi hedayati
cellular and molecular research center, research institute for endocrine sciences, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

علی اکبرنژاد | ali akbarnejad
college of physical education and sport sciences, university of tehran, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://phypha.ir/ppj/browse.php?a_code=A-10-930-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/26/article-26-327738.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Endocrinology
نوع مقاله منتشر شده Original Research
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