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Iranian Journal of Microbiology، جلد ۱۶، شماره ۵، صفحات ۶۷۶-۶۸۳
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عنوان انگلیسی Prevalence of JC polyomavirus among rheumatoid arthritis and systemic lupus erythematosus patients and its correlation with vitamin D levels
چکیده انگلیسی مقاله Background and Objectives: Vitamin D deficiency in viral infection associated with autoimmune diseases is well documented. This study assessed the prevalence of JC virus in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and its correlation with vitamin D level. Materials and Methods: Serum and urine samples were collected from 50 patients with RA and SLE. DNA was extracted and subjected to PCR test. Positive PCR products were sequenced, phylogenetic tree was constructed to determine the JC virus genotype. The patient’s vitamin D level was evaluated. Results: Of 50 patients, 19 (38%) were diagnosed as RA, and 31 (62%) were identified as SLE. JC virus DNA was detected in 17 (34%) patients’ urine samples including 5 (26.3%) RA and 12 (38.7%) SLE cases. JC virus DNA was detected 2 (4%) in patients’ serum samples (one RA. and one SLE). JC virus genotype 3A was dominant. Interestingly, the SLE patients with positive JC virus showed lowered vitamin D compared to patients with negative JC virus (P<0.005). Conclusion: Given the high rate of JC virus, DNA detection and susceptibility of patients for PML development, it is recommended that detection of JC virus DNA and vitamin D level should be implemented for patients with RA/SLE prior to treatment.
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نویسندگان مقاله | Golnaz Irani Mokhtari
Cellular and Molecular Research Center, Ahvaz Jundishapur University, Ahvaz, Iran; Department of Virology, Ahvaz Jundishapur University, Ahvaz, Iran


| Azarakhsh Azaran
Department of Virology, Ahvaz Jundishapur University, Ahvaz, Iran


| Elham Rajahi
Department of Rheumatology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Saeed Hesam
Department of Biostatistics and Epidemiology, Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Azam Dehghani Ghahfarokhi
Department of Virology, Ahvaz Jundishapur University, Ahvaz, Iran


| Manoochehr Makvandi
Cellular and Molecular Research Center, Ahvaz Jundishapur University, Ahvaz, Iran; Department of Virology, Ahvaz Jundishapur University, Ahvaz, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4724
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