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Iranian Journal of Microbiology، جلد ۱۶، شماره ۵، صفحات ۶۹۸-۷۰۷
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عنوان انگلیسی Biofilm formation and drug susceptibility of biofilm Candida spp. clinically isolated from nasopharyngeal cancer patients in Vietnam
چکیده انگلیسی مقاله Background and Objectives: The biofilm formation has been widely recognized as one of the main mechanisms of antimicrobial resistance development in microorganisms. However, few studies are focusing on this phenomenon in Candida spp. in clinical settings, especially on immuno-compromised patients. Materials and Methods: In this study, both the rate of biofilm formation in those patients and its drug susceptibility in initial and mature biofilm were assessed using crystal violet assay and dilution method. Results: The results demonstrated that the biofilm formation rate was similar between albicans and non-albicans Candida. However, the biofilm formation capacity was more pronounced in non-albicans Candida, especially, C. glabrata. As expected, there was a significant relationship between biofilm formation and drug resistance. In addition, our study reconfirmed that the age of high concentration of antifungal agents only affected Candida before its biofilm formation regardless of its biofilm formation capacity. In the contrary, once the biofilm was formed even elevated drug concentrations did not show sufficient efficacy, highlighting a need for high dosage at the early stage of treatment for those patients. Conclusion: The results of this study highlighted the importance of using appropriate antifungal agents for Candida treatment before the formation of biofilm.
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نویسندگان مقاله | Bac Nguyen
Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Medicine and Pharmacy, Ho Chi Minh, Vietnam


| Linh Tran
Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Medicine and Pharmacy, Ho Chi Minh, Vietnam


| Thanh-Hoa Vo
Department of Pharmacognosy and Traditional Pharmacy, University of Health Sciences, Vietnam National University Ho Chi Minh, Ho Chi Minh, Vietnam; Department of Pharmacognosy and Traditional Pharmacy, Research Center Discovery and Development of Healthcare Products,Vietnam National University Ho Chi Minh, Ho Chi Minh, Vietnam


| Anh-Tu Nguyen-Ha
Department of Pharmaceutics and Industrial Pharmacy, University of Health Sciences, Vietnam National University Ho Chi Minh, Ho Chi Minh, Vietnam


| Minh-Tri Le
Department of Pharmaceutics and Industrial Pharmacy, University of Health Sciences, Vietnam National University Ho Chi Minh, Ho Chi Minh, Vietnam


| Phuoc-Vinh Nguyen
Department of Pharmaceutics and Industrial Pharmacy, University of Health Sciences, Vietnam National University Ho Chi Minh, Ho Chi Minh, Vietnam; Department of Pharmaceutics and Industrial Pharmacy, Research Center Discovery and Development of Healthcare Products,Vietnam National University Ho Chi Minh, Ho Chi Minh, Vietnam
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/5000
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