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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۱۲، صفحات ۱۴۷۵-۱۴۹۱
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عنوان انگلیسی Targeting autophagy for breast cancer prevention and therapy: From classical methods to phytochemical agents
چکیده انگلیسی مقاله Breast cancer is a heterogeneous illness comprising diverse biological subtypes, each of which differs in incidence, response to therapies, and prognosis. Despite the presence of novel medications that effectively target vital cellular signaling pathways and their application in clinical practice, breast cancer can still develop resistance to therapies by various mechanisms. Autophagy is a conserved catabolic cellular process that maintains intracellular metabolic homeostasis by removing dysfunctional or unnecessary cellular materials to recycle cytosolic components. This process serves as an adaptive survival response to diverse stress stimuli, thereby contributing to tumor initiation, progression, and drug resistance, leading to restriction of the effectiveness of chemotherapeutic treatments. Regarding this potential role of autophagy, molecular regulation and signal transduction of this process represent an attractive approach to combat cancer development and drug resistance. Among various therapeutic agents, bioactive plant-derived compounds have received significant interest as promising anticancer drugs. A plethora of evidence has shown that phytochemicals with the capacity to modulate autophagy may have the potential to be used as inhibitors of breast cancer growth. In this review, we describe recent findings on autophagy targeting along with conventional methods for breast cancer therapy. Subsequently, we introduce phytochemical compounds with the capacity to modulate autophagy for breast cancer treatment.
کلیدواژه‌های انگلیسی مقاله Autophagy, Breast Cancer, Cell death, Phytochemicals, Targeted therapy
نویسندگان مقاله | Sadegh Rajabi
Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Heeva Shakib
Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Nahid Safari-Alighiarloo
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran


| Marc Maresca
Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, 13013 Marseille, France


| Maryam Hamzelo Moghadam
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_24704.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Article
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