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Iranian Biomedical Journal، جلد ۲۸، شماره ۲، صفحات ۵۹-۷۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of Cold Adaptation on the State of Cardiovascular System and Cardiac Tolerance to Ischemia/Reperfusion Injury
چکیده انگلیسی مقاله
Despite the unconditional success achieved in the treatment and prevention of AMI over the past 40 years, mortality in this disease remains high. Hence, it is necessary to develop novel drugs with mechanism of action different from those currently used in clinical practices. Studying the molecular mechanisms involved in the cardioprotective effect of adapting to cold could contribute to the development of drugs that increase cardiac tolerance to the impact of ischemia/reperfusion. An analysis of the published data shows that the long-term human stay in the Far North contributes to the occurrence of cardiovascular diseases. At the same time, chronic and continuous exposure to cold increases tolerance of the rat heart to ischemia/ reperfusion. It has been demonstrated that the cardioprotective effect of cold adaptation depends on the activation of ROS production, stimulation of the β2-adrenergic receptor and protein kinase C, MPT pore closing, and KATP channel.
کلیدواژه‌های انگلیسی مقاله Acclimatization, Cold temperature, Heart, Ischemia, Reperfusion
نویسندگان مقاله | Nikita S. Voronkov
Cardiology Research Institute, Tomsk National Research Medical Center of the RAS, Tomsk, Russia


| Sergey V. Popov
Cardiology Research Institute, Tomsk National Research Medical Center of the RAS, Tomsk, Russia


| Natalia V. Naryzhnaya
Cardiology Research Institute, Tomsk National Research Medical Center of the RAS, Tomsk, Russia


| N. Rajendra Prasad
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India


| Ivan M. Petrov
Tyumen State Medical University, Tyumen, Russia


| Viktor V. Kolpakov
Tyumen State Medical University, Tyumen, Russia


| Evgenia A. Tomilova
Tyumen State Medical University, Tyumen, Russia


| Ekaterina V. Sapozhenkova
Tyumen State Medical University, Tyumen, Russia


| Leonid N. Maslov
Cardiology Research Institute, Tomsk National Research Medical Center of the RAS, Tomsk, Russia
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5227-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Related Fields
نوع مقاله منتشر شده مقاله مروری
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