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Iranian Biomedical Journal، جلد ۲۸، شماره ۲، صفحات ۱۱۳-۱۱۹
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عنوان انگلیسی Curcumin Lowers the Accelerated Speed of Epileptogenesis by Traumatic Brain Injury
چکیده انگلیسی مقاله
Background: Traumatic brain injury or TBI can underlie epilepsy. Prevention of PTE has been of great interest to scientists. Given the antiepileptic, antioxidant and anti-inflammatory activities of curcumin, we examined whether this compound can affect epileptogenesis in rats after TBI.
Methods: Curcumin was injected once a day for two weeks. TBI was induced in the temporal cortex of anesthetized rats using a controlled cortical impact device. One day after TBI, pentylenetetrazole (PTZ), 35 mg/kg, was injected i.p. every other day until manifestation of generalized seizures. The number of PTZ injections was then recorded. Moreover, the extent of cortical and hippocampal IL-1β and glial fibrillary acidic protein (GFAP) expression in the epileptic rats were measured by Western blot analysis.
Results: Curcumin 50 and 150 mg/kg prevented the development of kindling, whereas TBI accelerated the rate of kindling. Curcumin 20 mg/kg prohibited kindling facilitation by TBI, and reduced the expression of IL-1β and GFAP induced by TBI.
Conclusion: Curcumin can stop the acceleration of epileptogenesis after TBI in rats. Inhibiting hippocampal and cortical overexpression of IL-1β and GFAP seems to be involved in this activity.
کلیدواژه‌های انگلیسی مقاله Glial fibrillary acidic protein, IL-1β, Post-traumatic epilepsy, Traumatic brain injury
نویسندگان مقاله | Hanieh Jahi
Department of Physiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mansoureh Eslami
Department of Basic Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mohammad Sayyah*
Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran


| Fariba Karimzadeh
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran


| Melika Alesheikh
Department of pharmacy, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5498-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Related Fields
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