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Iranian Biomedical Journal، جلد ۲۷، شماره ۵، صفحات ۲۸۰-۲۹۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Formulation and Characterization of a Novel Oxidized Alginate-Gelatin-Silk Fibroin Bioink with the Aim of Skin Regeneration
چکیده انگلیسی مقاله Background: In the present study, a novel bioink was suggested based on the oxidized alginate (OAlg), gelatin (GL), and silk fibroin (SF) hydrogels.
Methods: The composition of the bioink was optimized by the rheological and printability measurements, and the extrusion-based 3D bioprinting process was performed by applying the optimum OAlg-based bioink.
Results: The results demonstrated that the viscosity of bioink was continuously decreased by increasing the SF/GL ratio, and the bioink displayed a maximum achievable printability (92 ± 2%) at 2% (w/v) of SF and 4% (w/v) of GL. Moreover, the cellular behavior of the scaffolds investigated by MTT assay and live/dead staining confirmed the biocompatibility of the prepared bioink.
Conclusion: The bioprinted OAlg-GL-SF scaffold could have the potential for using in skin tissue engineering applications, which needs further exploration.
کلیدواژه‌های انگلیسی مقاله Alginate, Bioprinting, Fibroin, Gelatin
نویسندگان مقاله | Khadijeh Sanaei
Biomaterials Group, materials and energy research center


| Ali Zamanian
Biomaterials Group, materials and energy research center


| Shohreh Mashayekhan
Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran


| Tayebe Ramezani
Faculty of biological sciences, Kharazmi University, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5512-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Tissue Engineering and Cell Biology
نوع مقاله منتشر شده مقاله کامل
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