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Iranian Biomedical Journal، جلد ۲۷، شماره ۱، صفحات ۶۶-۷۱
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چکیده فارسی مقاله
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عنوان انگلیسی Alteration in Serum Levels of Tumor Necrosis Factor Alpha is associated with Histopathologic Progression of Gastric Cancer
چکیده انگلیسی مقاله Background: The role of inflammatory cytokines, such as tumor necrosis- alpha (TNF-α) and IL-8, in gastric carcinogenesis has been investigated, but their impact remains to be further elucidated.
Methods: In this study, we measured the serum concentrations of these cytokines and H. pylori serostatus in dyspeptic patients, presenting with normal mucosa (NM = 53), chronic gastritis (CG = 94), and gastric cancer (GC = 82), by ELISA.
Results: Moderate levels of TNF-α were detected in the NM group (19.9 ± 19.5 pg/ml), which were nearly doubled in patients with CG (35.7 ± 28.0 pg/ml) and drastically declined in GC patients (1.8 ± 5.9 pg/ml). The serum levels of IL-8, however, were not statistically different amongst these three groups.
Conclusion: TNF-α serum concentration seemed to undergo up- and downregulation, when moving from NM to CG and from CG to GC, respectively. If confirmed in a prospective study, this cytokine can behave as a serum indicator of gastric inflammation and malignant transformation.
کلیدواژه‌های انگلیسی مقاله Inflammation, Interleukin-8, cytokines, Tumor necrosis factor-alpha
نویسندگان مقاله | Mehdi Alikhani
HPGC Research Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran


| Maryam Esmaeili
HPGC Research Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran


| Mohammad Tashakoripour
Gastroenterology Department, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Ali Mohagheghi
Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran


| Mahmoud Eshagh Hosseini
Gastroenterology Department, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Eliette Touati
Institut Pasteur, Unit of Helicobacter Pathogenesis, CNRS UMR2001, 25-28 Rue du Dr Roux, 75724 Paris Cedex 15, France


| Massoud Vosough
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran


| Marjan Mohammadi
HPGC Research Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5173-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cancer Biology
نوع مقاله منتشر شده مقاله کوتاه
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