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Iranian Biomedical Journal، جلد ۲۶، شماره ۶، صفحات ۴۰۶-۴۱۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Antitumorigenic Effect of Cannabidiol in Lung Cancer: What Do We Know So Far?–A Mini Review
چکیده انگلیسی مقاله Lung cancer remains a major factor contributing to morbidity and mortality worldwide. cannabidiol (CBD) and Δ9-tetrahydrocannabinol could serve as a specific treatment for lung cancer, owing to their essential role in lung cancer cell apoptosis. This review evaluated the antitumorigenic mechanisms of CBD in lung cancer cells. We searched the databases MEDLINE, clinicaltrials.gov, Cochrane Central Register of Controlled Trials, and Google Scholar using specific terms. Of 246 studies screened, nine were included and assessed using the ToxRTool. All the selected studies were conducted in vitro, and four of which also had an in vivo content. The most common cell line used in all the studies was A549; however, some studies contained other cell lines, including H460 and H358. Our findings suggested that CBD has direct antineoplastic effects on lung cancer cells through various mechanisms mediated by cannabinoid receptors or independent of these receptors. All studies were referred to an in vitro model; hence, further research in animals is required.  
کلیدواژه‌های انگلیسی مقاله Cannabidiol, Cannabinoids, Lung cancer
نویسندگان مقاله | Vasileios Issares
Athens General Hospital 'Evangelismos, Athens, Greece


| Gerasimos panagiotis Milas
Penteli Children’s Hospital, Athens, Greece


| Nicholas Zareifopoulos
General Hospital of Nikaia Agios Panteleimon, Athens, Greece
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4843-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cancer Biology
نوع مقاله منتشر شده مقاله مروری
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