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Iranian Biomedical Journal، جلد ۲۶، شماره ۶، صفحات ۴۷۵-۴۸۴
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چکیده فارسی مقاله
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عنوان انگلیسی Combined Effect of Neutron Radiation and Curcumin on Breast Cancer Cells Cytotoxicity in 3D Culture Medium
چکیده انگلیسی مقاله Introduction: Chemotherapy, biotherapy, and radiotherapy play a limited but important role in treating breast cancer. For more efficient treatment, combination therapy could be an appropriate option. In this study, radiotherapy using neutron radiation emitted from a 241Am-Be neutron source, as well as biotherapy using curcumin (80 μM) was combined to investigate the efficiency of treatment towards MCF-7 breast cancer in a three dimensional (3D) culture medium.
Methods: MTT, neutral red uptake assay, nitric oxide, glutathione assay, catalase, cytochrome c, comet assay, and caspase-3 were used to determine the effect of neutron radiation and also neutron and curcumin combination on the viability of cancer cells.
Results: The results of cytotoxicity test showed that neutron irradiation with or without curcumin at 5, 10, 15, and 20 h reduced the survival of tumor cells. Moreover, the rate of apoptosis due to the neutron effect at different irradiation times enhanced with the increasing time.
Conclusion: Due to the significant anticancer effect of curcumin in 3D culture, using this molecule before or after neutron therapy is recommended.
کلیدواژه‌های انگلیسی مقاله Breast neoplasms, Curcumin, MCF-7 cells
نویسندگان مقاله | Sajedeh Zargan
Department of Medical Radiation Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran


| Mahdi Salehi Barough
Department of Medical Radiation Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran


| Jamil Zargan
Department of Biology, Faculty of Basic Sciences, Imam Hossein Comprehensive University, Tehran, Iran


| Mohsen Shayesteh
Department of Medical Radiation Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran


| Ashkan Haji Noor Mohammadi
Department of Biology, Faculty of Basic Sciences, Imam Hossein Comprehensive University, Tehran, Iran


| Mohsen Mousavi
Department of Biology, Faculty of Basic Sciences, Imam Hossein Comprehensive University, Tehran, Iran


| Hani Keshavarz Alikhani
Faculty of Science, Department of Biology, Razi University, Kermanshah, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4908-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cancer Biology
نوع مقاله منتشر شده مقاله کامل
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