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Iranian Biomedical Journal، جلد ۲۶، شماره ۵، صفحات ۳۴۰-۳۴۹
عنوان فارسی
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عنوان انگلیسی Role of Intravesical BCG as a Therapeutic Vaccine for Treatment of Bladder Carcinoma
چکیده انگلیسی مقاله
Bacterial products have attracted much attention as potential antitumor agents, with the ability to provide direct tumoricidal effects, leading to the inhibition of tumor growth. Treatment of superficial bladder cancer with intravesical Bacillus Calmette-Guérin (BCG) has a more reduction potential than surgery in tumor recurrence rate. BCG, the gold standard for nonmuscle invasive bladder cancer, is manufactured from different strains and produced commercially with varied strengths. There are a few countries known as the manufacturer of this strategic biopharmaceutical product, and Iran as a member of the Eastern Mediterranean Region plays a vital role in supplying this vaccine. Studies have failed to uncover the exact mechanism of action of the intravesical; however, evidence points toward an immunogenic mechanism that proficiently modifies a biologic response and provokes the immune cells in order to kill and suppress tumors. Among various underlying mechanisms, BCG bacillus attachment to fibronectin through its fibronectin attachment protein is a pivotal mechanism for BCG tumoricidal activity.
 
کلیدواژه‌های انگلیسی مقاله BCG, Bladder carcinoma, Bacterial products
نویسندگان مقاله | Delaram Doroud
Production and Research Complex , Pasteur Institute of Iran, Tehran, Iran


| Hamidreza Hozouri
Department of Quality Management, Pasteur Institute of Iran, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4725-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Related Fields
نوع مقاله منتشر شده مقاله مروری
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