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Iranian Biomedical Journal، جلد ۲۶، شماره ۵، صفحات ۳۵۰-۳۵۶
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عنوان انگلیسی Dynamic Population of Gut Microbiota as an Indicator of Inflammatory Bowel Disease
چکیده انگلیسی مقاله Background: Inflammatory bowel disease is a chronic inflammatory disease of the gastrointestinal tract. The gut microbiota is an important factor in the pathogenesis of inflammatory bowel disease (IBD). Due to a link between the gut microbiota and IBD, studying microbiota changes using an accurate, sensitive and rapid method for detection of the disease seems necessary. This study aimed to compare the composition of gut microbiota in three groups of people, including IBD patients, cured Inflammatory bowel disease (CIBD), and healthy groups.
Methods: For this study, 45 stool samples (15 from each group) were collected. Using real-time PCR, the abundance of 11 bacterial 16S rRNA gene sequences was examined.
Results: In the IBD group, the number of three bacterial phyla, including Firmicutes, Actinobacteria, and Bacteroidetes, decreased (p < 0.01, p < 0.01, and p < 0.001, respectively), while the population of γ-Proteobacteria increased significantly (p < 0.0001). In the CIBD group, the number of Actinobacteria enhanced (p < 0.01), but that of Bacteroidetes and Firmicutes decreased (p < 0.01, and p < 0.05, respectively).
Conclusion: Findings of this study indicate that decrease in Firmicutes and increase in γ-Proteobacteria could be used as an indicator of IBD instead of employing invasive and costly detection methods such as colonoscopy and other tests.
کلیدواژه‌های انگلیسی مقاله Inflammatory bowel disease, Microbiota, Real-time polymerase chain reaction
نویسندگان مقاله | Afsaneh Salimi
Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran


| Amin Sepehr
Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran


| Hossein Ajdarkosh
Gastrointestinal and Liver Disease Research Center, Firoozgar Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Shadi Aghamohamad
Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran


| Maliheh Talebi
Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Mahdi Rohani*
Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran


| Mohammad Reza Pourshafie
Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5014-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Molecular Microbiology
نوع مقاله منتشر شده مقاله کامل
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