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Iranian Biomedical Journal، جلد ۲۶، شماره ۲، صفحات ۱۱۰-۱۱۵
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عنوان انگلیسی Validating MARK2 Gene Polymorphism as a Predictor of Response to Lithium Treatment in Bipolar Patients
چکیده انگلیسی مقاله Background: Lithium is a therapeutic option for the treatment of the acute phase of the bipolar disorder and long-term management of this disorder. However,  it  is  estimated  that  10  to  60%  of  patients  do  not  properly response to this medication.
Methods: To investigate the role of MARK2 gene in response to lithium, we genotyped the MARK2 rs10792421 polymorphism in Iranian bipolar patients using amplification Refractory Mutation System-PCR.
Results: Results of this study showed a significant association of this polymorphism with response to lithium. The A allele was more frequent in the  responder  than  the  non-responder  group  and  also  in  the  semi- responder group compared to the non-responder group in the codominant model of analysis. AA and AG genotypes were more frequent in both the responder and semi-responder groups compared to the non-responder group in dominant model of analysis.
Conclusion: Based on the findings of the current study, the rs10792421 variant of MARK2 gene could be considered as a potential biomarker for predicting the treatment outcome of bipolar disorder type 1 in Iranian population.
کلیدواژه‌های انگلیسی مقاله Bipolar, Biomarkers, Lithium, Genotyping
نویسندگان مقاله | Sara Sadat Aghabozorg Afjeh
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Jamal Shams
Behavioral Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Safar Hamednia
Department of Psychiatry, Urmia University of Medical Sciences, Urmia, Iran


| Behzad Boshehri
Department of Forensic Medicine and Toxicology, Urmia University of Medical Sciences, Urmia, Iran


| Asmaolhosna Amini
Sara Medical Genetics Laboratory, Tehran, Iran;


| Amin Omrani
Faculty of Medicine of Tehran University of Medical Sciences, Tehran, Iran


| Mir Davood Omrani
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4348-2&slc_lang=en&sid=1
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