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Iranian Biomedical Journal، جلد ۲۵، شماره ۶، صفحات ۴۲۶-۴۳۳
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چکیده فارسی مقاله
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عنوان انگلیسی Molecular Investigation of Human Cytomegalovirus and Epstein-Barr virus in Glioblastoma Brain Tumor: A Case-Control Study in Iran
چکیده انگلیسی مقاله Background: Glioblastoma multiforme is the most invasive and lethal form of brain cancer with unclear etiology. Our study aimed to investigate the molecular prevalence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) infections in patients with glioblastoma multiforme (GBM). Methods: This case-control study was conducted on 42 FFPE brain tumor samples from GBM patients and 42 brain autopsies from subjects without neurological disorders. The presence of EBV and HCMV DNA was determined, using PCR and nested-PCR assays, respectively. Results: HCMV DNA was detected in 3 out of 42 (7.1%) of GBM samples and was absent from the control group (p = 0.07). Importantly, EBV DNA was detected in 9 out of 42 (21.4%) brain tissue specimens of GBM subjects, but again in none of the control group (p = 0.001). Conclusion: Our findings indicate that infection with EBV is associated with GBM.
کلیدواژه‌های انگلیسی مقاله Brain tumor, Epstein-Barr virus, Glioblastoma, Human cytomegalovirus
نویسندگان مقاله | Hadi Ghaffari
1Department of Bacteriology and Virology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran


| Ahmad Tavakoli
Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran


| Mohammad Faranoush
Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran


| Ali Naderi
Mahak Pediatric Cancer Treatment and Research Center, Tehran, Iran


| Seyed Jalal Kiani
Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Alireza Sadeghipour
Department of Pathology, Hazrat-e-Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran


| Davod Javanmard
Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran


| Mohammad Farahmand
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Saied Ghorbani
Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Farnoush Sedaghati
Department of Pathology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Seyed Hamidreza Monavari
Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-3792-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Molecular Microbiology
نوع مقاله منتشر شده مقاله کامل
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