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Iranian Biomedical Journal، جلد ۲۵، شماره ۴، صفحات ۳۰۳-۳۰۷
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عنوان انگلیسی Valproic Acid Ameliorates Locomotor Function in the Rat Model of Contusion via Alteration of Mst1, Bcl-2, and Nrf2 Gene Expression
چکیده انگلیسی مقاله Background: In animal models of inflammatory diseases, Mammalian sterile 20-like kinase 1 (Mst1) facilitates the programmed cell death as a novel pro-apoptotic kinase. This research aimed to determine the expression level of Mst1 gene in a rat model of SCI treated with valproic acid (VPA). Methods: Severe rat model contusion was used for evaluation of the neuroprotective effect of valproic acid. The Basso-Beattie-Bresnahan test, was performed to determine locomotor functions. Hematoxylin/eosin staining and TUNEL assay were performed to detect cavity formation and apoptosis, respectively. The mRNA levels of the genes Mst1, nuclear factor (erythroid-derived 2)-like 2, and B-cell lymphoma 2 were evaluated, using quantitative real-time PCR acute spinal cord injury (RT-PCR). Results: The results revealed that Mst1 gene expression and TUNEL-positive cells in the VPA-treated group were significantly reduced as compared to the untreated group (p ≤ 0.05). Conclusion: Our findings indicate that VPA has therapeutic potential and can be a candidate for the treatment of neurodegenerative disorders and traumatic injury as a promising drug.
کلیدواژه‌های انگلیسی مقاله Bcl-2, Contusion, Mst1, Nrf2, Valproic acid
نویسندگان مقاله | Ali Mardi
Department of Molecular Medicine and Genetics, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran


| Alireza Biglari
Department of Molecular Medicine and Genetics, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran


| Reza Nejatbakhsh
Department of Anatomy, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran


| Alireza Abdanipour
Department of Anatomy, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-538-4&slc_lang=en&sid=1
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