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Avicenna Journal of Phytomedicine، جلد ۱۴، شماره ۶، صفحات ۷۶۴-۷۷۵
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عنوان انگلیسی Perillyl alcohol, quercetin, and berberine combination therapy ameliorates experimental pulmonary arterial hypertension: Effects on the lung miR-204 expression, remodeling, and inflammatory factors
چکیده انگلیسی مقاله Objective: Pulmonary artery hypertension (PAH) is a devastating syndrome. Our previous studies showed that perillyl alcohol (P), berberine (B) and quercetin (Q) improve PAH. In this study, we investigated the effects of sub-effective doses of these derivatives in double and triple combination forms on PAH in rats.Materials and Methods: Forty nine rats were divided into seven groups (n=7): 1) control, 2) monocrotaline (MCT), 3) MCT+vehicle (veh), 4) MCT+BP, 5) MCT+PQ, 6) MCT+BQ, and 7) MCT+BPQ. After three weeks of PAH induction with MCT (60 mg/kg), either vehicle (ethanol 5% in saline) or one of the above combinations (dose of 20 mg/kg for B, and doses of 20 and 10 mg/ kg for P and Q in vehicle) was administered for three weeks. Right ventricular (RV) pressure, contractility indices, lung pathology, miR-204 expression, oxidative stress markers, inflammation and apoptosis were assayed.Results: MCT increased RV systolic pressure and hypertrophy, and lung arteriole wall thickness, fibrosis and leukocyte infiltration in the MCT group compared to the CTL group. All treatments improved these effects significantly. Furthermore, MCT reduced antioxidant factors, Bax, P21 and miR-204 expression and increased Tumor Necrosis Factor alpha (TNF-α), Interleukin 6 (IL-6) and Bcl-2. All of these effects were recovered by combination treatments.Conclusion: The results showed that combination therapy with sub-effective/ineffective doses of these compounds had ameliorative effects against PAH. 
کلیدواژه‌های انگلیسی مقاله Pulmonary Artery Hypertension, Perillyl alcohol, Berberine, Quercetin, Combination therapy, miR-204
نویسندگان مقاله | Zeinab Kordestani
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran


| Ahmad Beik
Gastroenterology and Hepathology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Science, Kerman, Iran


| Hamid Najafipour
Department of Physiology and Pharmacology, Afzalipour Medical Faculty, and Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran


| Zohreh Safi
Endocrinology and Metabolism Research Center, Kerman University of Medical Sciences, Kerman, Iran


| Majid Askaripour
Department of Physiology, School of Medicine, Bam University of Medical Sciences, Bam, Iran


| Soodeh Rajabi
Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Science, Kerman, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_24522.html
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نوع مقاله منتشر شده Original Research Article
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