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Journal of Medical Microbiology and Infectious Diseases، جلد ۱۱، شماره ۱، صفحات ۶۰-۶۱
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عنوان انگلیسی Intraventricular Administration of Cefepime for the Treatment of Meningitis due to Pseudomonas aeruginosa
چکیده انگلیسی مقاله Beta-lactam antibiotics are traditionally not considered for intrathecal therapy, despite their poor penetration into the cerebrospinal fluid (CSF) during intravenous therapy, because target concentrations of the beta-lactam antibiotic in the central nervous system can usually be achieved with a higher intravenous dose [1]. However, in cases where inadequate clinical response is seen even with maximal doses of intravenous antibiotics, and when access for intraventricular administration of antibiotics is available, this route can be utilized for patient management, as we report now. Cefepime at high doses has been reported to cause seizures and encephalopathy [2]. However, therapeutic intraventricular administration of cefepime for the management of nosocomial meningitis, leading to successful microbiological clearance has not been reported previously in the literature.
کلیدواژه‌های انگلیسی مقاله Intraventricular, Cefepime, Pseudomonas
نویسندگان مقاله | Sameer Abdul Samad
Department of Infectious Diseases, Aster Malabar Institute of Medical Sciences, Calicut, India


| Hafeedha Kallarakkal
Department of Clinical Pharmacy, Aster Malabar Institute of Medical Sciences, Calicut, India


| Noufal Basheer
Department of Neurosurgery, Aster Malabar Institute of Medical Sciences, Calicut, India
نشانی اینترنتی http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-451-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Anti-microbial agents, resistance and treatment protocols
نوع مقاله منتشر شده Letter to the Editor
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