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Journal of Medical Microbiology and Infectious Diseases، جلد ۱۰، شماره ۴، صفحات ۱۸۶-۱۹۱
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عنوان انگلیسی The adeH and adeS Efflux Pump Genes in Imipenem and Colistin-Resistant Acinetobacter baumannii Clinical Isolates
چکیده انگلیسی مقاله Introduction: Acinetobacter baumannii is one of the most important causes of nosocomial infections. In this bacteria, several mechanisms contribute to resistance against antimicrobial agents. The present study investigated the prevalence of adeS and adeH genes and the role of efflux pumps in imipenem and colistin-resistant A. baumannii clinical isolates. Methods: This study included 60 A. baumannii isolates collected from medical centers affiliated with the Shahid Beheshti University of Medical Science, Tehran, Iran. The antibiotic susceptibility pattern was examined using the broth microdilution MIC method according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Also, the adeS and adeH genes were amplified by PCR. Results: The isolates were 100% imipenem-resistant and 86.7% colistin-resistant. All isolates were positive for the 51-blaOXA gene. The adeH and adeS genes were detected in 95% and 80% of the isolates. Conclusion: The high frequency of adeS and adeH efflux pump genes and the high drug resistance in A. baumannii clinical isolates indicated that adeS and adeH efflux pump genes contribute to antibiotic resistance in this species. Therefore, our results provide essential information about high drug resistance in A. baumannii clinical isolates that can help limit the horizontal and vertical transmission of efflux pump genes in antibiotic-resistant A. baumannii isolates that causes nosocomial infections in susceptible strains.
کلیدواژه‌های انگلیسی مقاله Acinetobacter baumannii, Efflux pump, adeS gene, adeH gene
نویسندگان مقاله | Azam Aghili Amjad
Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran


| Mohammad Niakan
Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran


| Fatemeh Sameni
Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran


| Shahriar Bakhti
Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran


| Mansoor Khaledi
Biology Research Center, System Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Hamed Afkhami
Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran


| Reza Mirnejad
Biology Research Center, System Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-366-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Anti-microbial agents, resistance and treatment protocols
نوع مقاله منتشر شده Original article
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