این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Medical Microbiology and Infectious Diseases، جلد ۱۰، شماره ۴، صفحات ۱۹۹-۲۰۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Serum Interleukin-17, Transforming Growth Factor-beta Levels in Brucellosis Patients Before and After Treatment
چکیده انگلیسی مقاله Introduction: Brucellosis is a zoonotic disease in humans and animals and is a worldwide public health problem. Changes in inflammatory cytokines levels might be deployed as markers for diagnosing infectious diseases from non-infectious medical conditions. This study aimed to evaluate the relationship between serum levels of interleukin-17 (IL-17) and transforming growth factor-beta (TGF-β) in pediatric brucellosis. Methods: The present case-control study included 40 brucellosis patients and 40 matched healthy controls. Serum levels of inflammatory cytokines were measured by ELISA, and the independent student t-test was used to compare the levels in the brucellosis and healthy group. Serum cytokine levels before and after treatment were compared by the paired samples t-test. Results: The serum TGF-β level was significantly lower in the patients compared to the control group (90.21 ± 24.44 vs. 125.63 ± 23.28 pg/mL, P<0.nv001), and the serum interleukin-17 level was significantly higher in the case group (83.74 ± 23.57 vs. 25.95 ± 17.80 pg/ml, P<0.001). After treatment, serum IL-17 levels significantly decreased in the case group. Conclusion: In brucellosis patients, the serum IL-17 levels decreased significantly, whereas TGF-β increased significantly in these patients. Hence, the serum levels of these inflammatory cytokines can be indicators for diagnosing pediatric brucellosis.
کلیدواژه‌های انگلیسی مقاله Brucellosis, Interleukin-17, Transforming growth factor-beta
نویسندگان مقاله | Roozbeh Esalatmanesh
Medical Student, Kashan University of Medical Sciences, Kashan, Iran


| Mohammad Reza Sharif
Infections Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran


| Kamal Esalatmanesh
Department of Rheumatology, Kashan University of Medical Sciences, Kashan, Iran


| Shirin Heidari
Medical Student, Kashan University of Medical Sciences, Kashan, Iran


| Zahra Soleimani
Infections Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
نشانی اینترنتی http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-383-2&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Infectious diseases and public health
نوع مقاله منتشر شده Original article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات