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Journal of Cardio-Thoracic Medicine، جلد ۱۲، شماره ۲، صفحات ۱۳۲۳-۱۳۲۸
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عنوان انگلیسی The Predictive Role of MicroRNA19-b in Myocardial Infarction in Rat
چکیده انگلیسی مقاله Introduction: Cardiovascular disease is one of the leading causes of death worldwide. Acute myocardial infarction (AMI) is the most common and deadly disease of all types of cardiovascular disease. Many biomarkers such as troponin, CK-MB and various microRNAs have been shown to be involved in a variety of diseases, especially cardiovascular disease. Circulating MicroRNAs may be important and early biomarkers for the prognosis of cardiovascular disease. The aim of this study was to investigate the predictive role of miRNA-19b as a potential biomarker for AMI.Materials and Methods: In this case control method we divided 20 rats in Wistar breed (weight 250-300 g) into two groups of myocardial infarctions and healthy. Standard conditions such as a temperature of 25 ° C, enough water and food were created in the animal room of Mashhad Medical School. 150 mg of isoprenaline was dissolved in 2 ml of injected distilled water and the solution was injected subcutaneously for two days. 24 hours after the last injection, myocardial infarction was confirmed by assessment of (CK-MB and troponin).Results: Based on the findings, levels of troponin I and also CK-MB were higher in the group of rats induced myocardial infarction compared to healthy rats (P<0.001). In addition, the analyzes showed a significant up-regulation for miR-19b expression in the Treat group (P<0.001).Conclusions: These findings indicate that circulating miRNAs, especially microRNA 19b, could be excellent candidates as biomarkers for heart disease, especially EMI.
کلیدواژه‌های انگلیسی مقاله microRNAs, Cardiovascular Disease, Acute myocardial infarction, MicroRNA-19b
نویسندگان مقاله | Danial Falizkaran Yazdi
Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.


| Reza Sahebi
Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.


| Malihe Aghasizadeh
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.


| Naghmeh Azadi
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.


| Susan Darroudi
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.


| Hamideh Ghazizadeh
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.


| Maryam Mohammadi Bajgiran
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.


| Gordon A. Ferns
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN19PH, UK.


| Reza Assaran-Darban
Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.


| Majid Ghayour-Mobarhan
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
نشانی اینترنتی https://jctm.mums.ac.ir/article_25011.html
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