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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۱، شماره ۶۱، صفحات ۲۱-۳۲
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عنوان انگلیسی Malva sylvestris L. Protects from Fluoride Nephrotoxicity in Rat
چکیده انگلیسی مقاله Background: Malva sylvestris L. (M. sylvestris) has antioxidant property and is widely used in the traditional medicine to treat gastrointestinal, respiratory, skin and urological disorders. Objective: In this study, the protective effect of M. sylvestris against sodium fluoride-induced nephrotoxicity in the rat was evaluated. Methods: The M. sylvestris flower extract was prepared and injected intraperitoneally at the doses of 100, 200, 400 mg/kg/day to rat groups (10 in each group) for 1 week and subsequently 600 ppm sodium fluoride was added to the rats drinking water for 1 additional week. After these steps, the rat serum levels of urea, creatinine, reduced glutathione, catalase and malondialdehyde were determined. The histopathology of the rats' kidney was also studied. In this study, vitamin C (10 mg/kg/day) was used as positive control. Results: Sodium fluoride administration increased levels of BUN, creatinine, glutathione, catalase activity and decreased malondialdehyde levels indicating induction of nephrotoxicity in the rats. M. sylvestris extract pretreatment significantly decreased the BUN and creatinine levels (P< 0.05). Catalase activity and glutathione levels were significantly increased by M. sylvestris (P< 0.05). All three doses of the M. sylvestris decreased the malondialdehyde level, but it was significant only for the dose of 400 mg/kg/day (P< 0.05). The Malva sylvestris effects were comparable with those of vitamin C. Histopathological findings also showed protective effects of M. sylvestris against the renal damage induced by sodium fluoride. Conclusion: The results suggest that M. sylvestris has protective effects against sodium fluoride-induced nephrotoxicity which maybe mediated by the antioxidant activity of the plant flavonoids.
کلیدواژه‌های انگلیسی مقاله Malva sylvestris, Nephrotoxicity, Sodium fluoride, Rat
نویسندگان مقاله a بابایی زارچ | a babaei zarch
1- department of pharmacology, faculty of pharmacy, yazd shahid sadoughi university of medical sciences, yazd, iran


h فلاح حسینی | h fallah huseini
2- medicinal plants research center, institute of medicinal plants, acecr, karaj, iran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

s کیان بخت | s kianbakht
institute of medicinal plants, research complex of iranian academic center for education, culture and research acecr , p.o. box mehr villa 31375-369 karaj, iran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

p چنگایی | p changaei
1- department of pharmacology, faculty of pharmacy, yazd shahid sadoughi university of medical sciences, yazd, iran


a میرجلیلی | a mirjalili
3- department of biology and anatomical sciences, faculty of medicine, yazd shahid sadoughi university of medical sciences, yazd, iran


j صالحی | j salehi
1- department of pharmacology, faculty of pharmacy, yazd shahid sadoughi university of medical sciences, yazd, iran
نشانی اینترنتی http://jmp.ir/browse.php?a_code=A-10-71-26&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/88/article-88-329612.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده 1
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