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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۱، شماره ۳۳، صفحات ۱-۲۸
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عنوان انگلیسی The Anti-inflammatory and Anti-viral Effects of an Ethnic Medicine: Glycyrrhizin
چکیده انگلیسی مقاله The extract of licorice (Glycyrrhiza glabra L.) has been widely used for many centuries in the traditional Chinese medicine as native anti-allergic agent. Glycyrrhizin (GL), a triterpenoid-saponin, extracted from the roots of licorice is the most effective compound for inflammation and allergic diseases in human body. The biological and pharmacological studies revealed that GL possesses many pharmacological effects, such as anti-inflammatory, anti-viral and liver protective effects, and the biological effects, such as induction of cytokines (interferon-g and IL-12), chemokines as well as extrathymic T and anti-type 2 T cells. This review describes (i) the pharmacological property of GL as an effective anti-inflammatory and anti-viral drug (ii) the biochemical characteristics of several GL-binding proteins (gbPs) involved in the anti-inflammatory and anti-viral effects of 68GL and the GL-induced selective inhibition of the phosphorylation of these gbPs by GL-binding protein kinases in vitro and (iii) the mechanisms involved in the GL-induced inhibition of the replication of both RNA and DNA viruses. In addition, recent reports concerning the mechanical actions involved in the anti-inflammatory and anti-viral effects of GL in vivo and in vitro and its clinical effects on chronic active liver disease and viral infection are summarized.
کلیدواژه‌های انگلیسی مقاله Glycyrrhizin, Anti-inflammatory, Anti-viral, Review
نویسندگان مقاله f شمسا | f shamsa
department of pharmaceutical chemistry, faculty of pharmacy, tehran university of medical sciences, islamic republic of iran, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

k اهتسوکی | k ohtsuki
genetical biochemistry and signal biology, graduate school of medical sciences, kitasato university, 1-15-1 kitasato, sagamihara 228-8555, japan, tel, fax 81 – 42 - 778-8863


e حسن زاده | e hasanzadeh
cultivation and development department, institute of medicinal plants, acecr, karaj

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

sh رضازاده | sh rezazadeh
department of pharmacognosy and pharmaceutics, institute of medicinal plants, acecr, tehran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

نشانی اینترنتی http://jmp.ir/browse.php?a_code=A-10-415-1&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/88/article-88-329643.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده بیوشیمی
نوع مقاله منتشر شده پژوهشی
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