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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۱، شماره ۳۳، صفحات ۵۷-۶۵
عنوان فارسی
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عنوان انگلیسی Study of Hypoglycemic Effect of Juglans regia Leaves and its Mechanism
چکیده انگلیسی مقاله Background: Hypoglycemic effect of Juglans regia leaves was reported in other previous researches. Objective: To investigate the mechanism of hypoglycemic action of Julans regia Leaves Methanolic Extract (JRLME), we designed the following study. Methods: Male wistar rats were classified in five groups, each of six, including alloxan-induced diabetic rats treated with JRLME at doses of 250 (D+JRLMEa), 500 mg/kg (D+JRLMEb), Acarbose at dose 20 mg/kg (D+Ac), vehicle alone (DC) and normal rats treated with vehicle alone (NC). The Postprandial blood glucose level was examined in a short time (after a single dose treatment) and a long time (after three weeks daily treatment) model. After three weeks of treatment, all groups’ animals were killed to dissect pancreatic and myocardium for RNA extraction and RT-PCR, to assess insulin and glut-4 genes expression, respectively. In addition, other normal rats were killed to extract intestinal brush border membrane for α-glucosidase solution preparation. The effect of JRLMEa on α-glucosidase activity was evaluated by an in vitro method, compared to Acarbose as a reference drug. Results: The plant extract had a significant hypoglycemic action in both short and long term models. Decrease in PBG level was the most at 8 hour after treatment and more in D+Ac (53%), D+JRLMEa (40%) and D+JRLMEb (29%) versus DC, respectively. There was also permanent PBG reduction in treated groups in comparison with the DC one during long term period. Conclusion: We did not find change in the insulin and glut-4 genes expression. On the other hand, the in vitro assay of α-glucosidase activity displayed inhibitory action of JRLME, like Acarbose, but less effectively.
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نویسندگان مقاله m تیموری | m teimori
department of cellular and molecular biology, school of biology, faculty of science, university of tehran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

s منتصر کوهساری | s montasser kouhsari
department of cellular and molecular biology, school of biology, faculty of science, university of tehran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

r غفارزادگان | r ghafarzadegan
department of pharmacognosy and pharmaceutics, institute of medicinal plants, acecr, karaj, iran, tel 98-261-4764010-19, fax 98-2614764021

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

r حاجی آقایی | r hajiaghaee
department of pharmacognosy and pharmaceutics, institute of medicinal plants, acecr, karaj

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

نشانی اینترنتی http://jmp.ir/browse.php?a_code=A-10-218-2&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/88/article-88-329649.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده فارماکوگنوزی
نوع مقاله منتشر شده پژوهشی
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