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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۱، شماره ۳۳، صفحات ۸۶-۹۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Protective Effects of Nano-formulated Silymarin Against UV Radiation on Guinea Pig Skin
چکیده انگلیسی مقاله Background: As increased outdoor activities of people, they are more exposed to UV radiation, which causes harmful effects on skin. Silymarin has protective potentials against DNA damage and non-melanoma skin cancers, and also it has anti-oxidant, anti-inflammatory, and immune regulation characteristics. Nano formulation of plant material showed to be more effective than common ones. Objective: In present study, nano-formulated silymarin was used in a cream, and its effects were investigated against destructive effects of UV rays. Methods: Silymarin standardized extract was prepared, nano formulated in cream base, and applied to skin of the animals. Four groups of animals (n=15) were examined Group 1 without any treatment (control), Group 2 Vaseline, Group 3 nano-formulated silymarin extract cream, and Group 4 silymarin-carnosine. UV was radiated on the shaved area of the four groups for 45 minutes with dose of 180 mJ/cm2. Dermal scaling, skin irregularity, erythema, skin hyperpigmentation, and edema were evaluated in animals. Histopathological observation was done on the skin samples of the animals. Results: silymarin nano-formulation was effective in decreasing both physical damages and histopathological injuries significantly. Conclusion: from the observed results, it can be concluded that the cream containing nano-formulated silymarin can prevent UV radiation lesions better than pure silymarin.
کلیدواژه‌های انگلیسی مقاله Nano-formulation, Silymarin, UV protection, Guinea Pig
نویسندگان مقاله hr احمدی آشتیانی | hr ahmadi ashtiani
department of clinical biochemistry, school of medical science, tarbiat-e-modarres university, tehran, iran amp;amp; biochemistry and nutrition department, zanjan university of medical sciences, zanjan

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

sh رضازاده | sh rezazadeh
institute of medicinal plants, acecr, tehran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

e برخورداری | e barkhordari
tehran university of medical science, tehran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

n حکمت ناظمی | n hekmat nazemi
institute of medicinal plants, acecr, tehran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

m بقایی | m baghaei
cosmetics industry researcher, tehran


s بکایی | s bokaie
faculty of veterinary, university of tehran, tehran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

h رستگار | h rastegar
ministry of health and medical education, food amp;amp; drug laboratory research center, tehran, iran, tel amp;amp; fax 98-21-66462876

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

نشانی اینترنتی http://jmp.ir/browse.php?a_code=A-10-201-3&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/88/article-88-329653.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده کنترل غذا و دارو
نوع مقاله منتشر شده پژوهشی
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