این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۱، شماره ۲۵، صفحات ۴۴-۴۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Trypanocidal Activity of Some Medicinal Plants Against the Epimastigotes of Trypanosoma cruzi
چکیده انگلیسی مقاله Background: Some of medicinal plants are a potential source of new drugs to improve the treatment of Chagase disease whose treatment is still a challenge. Here in this screening, the in vitro trypanocidal activity of some fractions for 16 medicinal plants, collected from the northern part of Iran, has been reported. Methods: Aerial parts of the plants were dried carefully and followed by extraction with hexane and methanol, successively, by maceration at room temperature. Different concentrations of the plant extracts in ethanol were investigated against the epimastigotes of T. cruzi. The movement of epimastigotes was observed under a microscope. We assumed that immobilized organisms were died. The negative control contained ethanol in the same proportion utilized to dissolve the drugs. Each assay was performed in duplicate together with gentian violet as a positive control. Results: Results show that hexane extracts of Rubus hyrcanus and Salvia sclerae have been observed the most activity against the epimastigotes of T. cruzi (MLC = 12.5 m g/ml). None of methanol fractions shows trypanocidal activity except Salvia sclerae (MLC = 50 m g/ml). Echium amoenum, Satureja macrantha, S. atropatana and Stachys laxa did not display activity lower than 100 m g/ml in both hexane and methanol extracts.Conclusions: Some of Iranian medicinal plants (Salvia sclerae, Marrubium vulgare and Rubus hyrcanus) could be the promising source of active components against the epimastigotes of T. cruzi and need to further phytochemical and pharmacological studies.
کلیدواژه‌های انگلیسی مقاله Trypanocidal activity, Salvia sclerae, Rubus hyrcanus
نویسندگان مقاله ar گوهری | ar gohari
medicinal plants research center, faculty of pharmacy, medical sciences university of tehran, tehran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

s سعیدنیا | s saeidnia
medicinal plants research center, medical sciences university of tehran, p.o.box 14155-6451, tehran, iran, tel 98-21-66959090, fax 98-21-66461178

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

a حاجی آخوندی | a hadjiakhoondi
department of pharmacognosy, faculty of pharmacy, medical sciences university of tehran, tehran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

a naghinejad | a naghinejad
department of botany, faculty of sciences, university of tehran, tehran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

t yagura | t yagura
department of pharmacognosy, graduate school of pharmaceutical sciences, kyoto university, kyoto, japan
نشانی اینترنتی http://jmp.ir/browse.php?a_code=A-10-161-5&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/88/article-88-329663.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده فارماکوگنوزی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات