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Research in Pharmaceutical Sciences، جلد ۱۹، شماره ۵، صفحات ۶۲۲-۶۳۳
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی SIRT1/NOX1 pathway mediated ameliorative effects of rosmarinic acid in folic acid-induced renal injury
چکیده انگلیسی مقاله Background and purpose: Renal injury is a serious disorder that can be caused by some diseases or agents. Rosmarinic acid (RA) is a natural and safe compound with powerful antioxidant and anti-inflammatory properties. In this study, the ameliorative effects of RA were assayed in folic acid (FA)-induced renal injury by involving the SIRT1/NOX1 pathway. Experimental approach: Thirty-six male C57/BL6 mice were divided into 6 groups (n = 6) including control, vehicle, FA, RA, FA + RA 50, and FA + RA 100. After 10 days, blood urea nitrogen (BUN), creatinine, and oxidative stress were measured. The expression of SIRT1 and NOX1 proteins was evaluated by western blot. Also, histopathological alterations were assayed by H&E and PAS staining methods. Findings/Results: BUN and creatinine were significantly higher in the FA group compared to the control group; however, their levels decreased after RA treatment in both doses. A significant decrease was observed in swelling, necrosis, and desquamation of tubular epithelial cells in the FA + RA 50 and FA + RA 100 groups compared to the FA group. RA in the animals receiving FA increased SIRT1 expression and the levels of GSH and SOD compared to the FA group. RA in the animals receiving FA showed a significant decrease in NOX1 expression and MDA level compared to the FA group. Conclusion and implications : The findings declared that the administration of RA has positive effects against renal damage induced by FA. The effect might result from involvement in the SIRT1/NOX1 pathway and thereby attenuation of oxidative stress.    
کلیدواژه‌های انگلیسی مقاله Folic acid,NOX1,Renal failure,Rosmarinic acid,SIRT1.
نویسندگان مقاله | Maryam Mottaghi
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, I.R. Iran.


| Akram Eidi
Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, I.R. Iran.


| Fatemeh Heidari
Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, I.R. Iran.


| Tahereh Komeili Movahhed
Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, I.R. Iran. Department of Physiolgy, Faculty of Medicine, Qom University of Medical Sciences, Qom, I.R. Iran.


| Azam Moslehi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2277
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