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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۳، صفحات ۱۷۸-۰
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عنوان انگلیسی Kidney function in obese adolescents with or without metabolic syndrome in a nationally‑representative sample of pediatric population: First report from the Middle East and North Africa: The CASPIAN‑III Study: A Case‑Control Study
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Background: Obesity in accordance with metabolic syndrome (MetS) confronts populations at the higher risk of morbidity and mortality of chronic diseases including, chronic kidney diseases (CKD). The renal complication of obesity and MetS has been less debated in young adolescents. the objective of this study was to assess the kidney function in obese adolescents with or without MetS. Materials and Methods: The data used in this study were collected as part of a national study entitled childhood and adolescence surveillance and prevention of adult non-communicable disease study. The present study was conducted on a sub-sample of 113 obese adolescents (body mass index >95th percentile) aged between 10 years and 16 years selected by convenient sampling from the whole population studied. Anthropometric indexes and blood pressure were examined. A 12-h fasting serum was obtained for each participant to measure blood glucose, lipid profile, quantitative CRP(HS-CRP), cystatin-c, urea, and creatinine. Fasting spot urine was collected to determine microalbumin and creatinine. Based on the study findings, participants were assigned into two groups with and without MetS. Results: The mean of microalbuminuria was in similar ranges in two groups and while the mean glomerular filtration rate (GFR) calculated by Bokenkamp’s, updated and combined Schwartz’s formulas were significantly lower in MetS + obese group in comparison with obese group. The similar result was not achieved by filler’s formula. Among MetS components, waist circumference had a correlation with HS-CRP(p = 0.04; r = 0.15). GFR was calculated based on the Schwartz formula and cystatin-c formulas had no significant correlation with any MetS components. Conclusion: Our findings suggest that MetS can increase the risk of kidney dysfunction in obese adolescents. More studies are suggested in this regard in the pediatric population.
کلیدواژه‌های انگلیسی مقاله Kidney function, obesity, pediatric metabolic syndrome
نویسندگان مقاله رویا کلیشادی | roya kelishadi
department of pediatrics, child growth and development research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

آلاله قیصری | alaleh gheissari
department of pediatric nephrology, isfahan kidney diseases research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

ندا بازوکار | neda bazookar
child growth and development research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد اسماعیل مطلق | mohammad esmaeil motlagh
department of school health, bureau of population, family, and school health, ministry of health and medical education, tehran, iran

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

مهناز تسلیمی | mahnaz taslimi
department of school health, bureau of health and fitness, ministry of education, tehran, iran


گلایول اردلان | gelayol ardalan
department of school health, bureau of population, family, and school health, ministry of health and medical education, tehran, iran

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8999
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/218/article-218-330979.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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