| چکیده انگلیسی مقاله |
Normal 0 false false false EN-US X-NONE AR-SA Background: Contrast induced kidney injury is an acute renal dysfunction that is secondary to the administration of radio contrast media. The purpose of this study was to evaluate the levels of urotensin-II (UT-II) and endothelin-I (ET-I) after contrast media administration in patients undergoing percutaneous coronary interventions. Materials and Methods: In this prospective cohort study, we evaluated 78 patients with coronary artery disease who were scheduled for and ultimately underwent percutaneous coronary interventions. As a contrast material, nonionic contrast media was used in various amounts (70-480 mL). Blood and urine samples were obtained to measure U-II, ET-I just before and at the twenty-fourth hour of percutaneous coronary interventions. Results: Compared to baseline, twenty-fourth hour creatinine levels were significantly increased ( P < 0.001). The twenty-fourth hour serum and urine levels of both UT-II and ET-I were also significantly increased compared to baseline ( P < 0.001 for all) and 24 th hour serum and urine UT-II (r = 0.322, P = 0.004; r = 0.302, P = 0.007 respectively), ET-I (r = 0.511, P < 0.001; r = 0.266, P = 0.019 respectively) levels were significantly correlated with the amount of contrast media. Conclusion: Our study indicates that; increased UT-II and ET-I levels seem to be a consequence of hazardous effects of contrast media on blood vessels and the kidney. |
| نویسندگان مقاله |
turgay ulas | turgay ulas
departments of internal medicine, faculty of medicine, harran university, sanliurfa, urfa, turkey
حاکان buyukhatipoglu | hakan buyukhatipoglu
department of internal medicine, division of medical oncology, faculty of medicine, gaziantep university, gaziantep, turkey
مهمت s دال | mehmet s dal
department of internal medicine, faculty of medicine, dicle university, diyarbakir, turkey
ادریس kirhan | idris kirhan
departments of internal medicine, faculty of medicine, harran university, sanliurfa, urfa, turkey
zekeriya kaya | zekeriya kaya
departments of cardiology, faculty of medicine, harran university, sanliurfa, urfa, turkey
مهمت e demir | mehmet e demir
departments of medicine, division of nephrology, faculty of medicine, harran university, sanliurfa, urfa, turkey
عرفان tursun | irfan tursun
department of internal medicine, igdir training and research hospital, igdir, turkey
مهمت a eren | mehmet a eren
departments of internal medicine, faculty of medicine, harran university, sanliurfa, urfa, turkey
timucin aydogan | timucin aydogan
departments of internal medicine, faculty of medicine, harran university, sanliurfa, urfa, turkey
یوسف sezen | yusuf sezen
departments of cardiology, faculty of medicine, harran university, sanliurfa, urfa, turkey
nurten aksoy | nurten aksoy
departments of biochemistry, faculty of medicine, harran university, sanliurfa, urfa, turkey
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