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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۳، صفحات ۲۲۵-۰
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عنوان انگلیسی Serum gastrin 17, pepsinogen I and pepsinogen II in atrophic gastritis patients living in North-East of Iran
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Background: Gastric carcinoma is the second most common cause of cancer-related death in Iran. It is well-known that atrophic gastritis is a major risk factor for gastric cancer, which leads to variations in the serum levels of gastrin 17 (G-17), pepsinogen I (P-I), and pepsinogen II (P-II). The aim of this study was to investigate the diagnostic accuracy of these serum biomarkers in the early detection of atrophic gastritis. Materials and Methods: A total of 132 dyspeptic patients underwent upper endoscopy and biopsies were taken. The biopsy specimens were evaluated as the gold standard according to operative link for gastritis assessment staging system. Serum levels of G-17, P-I, and P-II were investigated using enzyme-linked immunosorbent assay. Receiver operating characteristic (ROC) analysis was used to calculate the diagnostic indices and optimal cut-off values using Statistical Package for the Social Sciences SPSS statistical software. Results: A total of 67 men and 65 women were analyzed, among which 48 (36.4%) had atrophic gastritis. The mean age was 45.8 (±15.8) years. ROC curve analysis demonstrated that the biomarkers (including pepsinogen I/II [ P-I/II] ratio), except for P-I , are diagnostically significant in detecting gastric atrophy. The area under the curve (95% confidence interval [CI]) for G-17 , P-I , P-II , and P- I/II ratio were 0.65 (0 .55-0.76 ), 0.42 (0 .32-0.53 ), 0.62 (0 .52-0.72 ), and 0.61 (0 .50-0.72 ), respectively. However, the diagnostic indices were low (sensitivity < 50%, specificity < 90%). The prevalence of Helicobacter pylori infection was significantly higher in patients with atrophy against those without atrophy (75.0% vs. 57.4%, P value < 0.0001). Conclusion: In the studied population, the serum biomarkers of atrophic gastritis are not useful screening tests due to their low sensitivity.
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نویسندگان مقاله موسی الرضا حسینی | mosalreza hosseini
department of gasteroenterology, ghaem hospital, mashhad university of medical sciences, mashhad, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سکینه عموییان | sakineh amoueian
department of pathology, imam-reza hospital, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

آرمین عطاران زاده | armin attaranzadeh
department of molecular pathology and cytogenetics, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مهدی منتظر | mehdi montazer
department of pathology, imam-reza hospital, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

قدرت اله سلطانی | ghodratollah soltani
department of gasteroenterology, ghaem hospital, mashhad university of medical sciences, mashhad, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

خیرالله اسداللهی | khairollah asadollahi
department of epidemiology, faculty of medicine, ilam university of medical sciences, ilam, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences)

قباد آبانگاه | ghobad abangah
department of gasteroenterology, ghaem hospital, mashhad university of medical sciences, mashhad, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9007
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/218/article-218-330988.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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