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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۳، صفحات ۲۳۴-۰
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عنوان انگلیسی Serum cryoglobulins and disease activity in systematic lupus erythematosus
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Background: To determine the prevalence of cryoglobulins in Iranian patients with systemic lupus erythematosus (SLE) and evaluate the correlation of cryoglobulins with disease activity in these patients. Materials and Methods: In a cross-sectional study, we investigated 80 consecutive women who fulfilled the 1982 revised criteria of the American College of Rheumatology for the classification of SLE. All the patients had undergone a medical interview and general physical examination by a rheumatologist for clinical and serologic characteristics of SLE. For the determination of cryoglobulins, sera were collected by a standard protocol at 37 °C, and after incubation at 4 °C for seven days, the level of cryoglobulins was estimated for each patient. Results: Cryoglobulins were detected in the sera of 39 (48.8%) patients. All of these patients had cryocrit over 5%. Disease was active in 30 patients [SLEDAI ≥6 (DAI: disease activity index)] and inactive in 50 (SLEDAI < 6). There was no significant difference between active and inactive patients for the presence of serum cryoglobulins (r =0.086, p =0.56). A significant positive correlation was observed between antinuclear antibody (ANA), anti-dsDNA (dsDNA: double-stranded Deoxyribonucleic acid), CH50 (CH50: total hemolytic complement assay), and C-reactive protein (CRP) (r =0.21, p =0.004, r =0.65, p =0.001, r =0.45, p =0.023, r =0.38, p =0.036, respectively). Hepatitis C virus (HCV) infection was not detected in any of the SLE patients. Conclusion: Although the presence of cryoglobulins in the SLE patients correlated with positive anti-ds DNA and low CH50, it could not be predict activity of the disease.
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نویسندگان مقاله منصور کریمی فر | mansoor karimifar
departments of rheumatology, school of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سمانه پورعجم | samaneh pourajam
departments of internal medicine, school of medicine and student research committee, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

افشین طهماسبی | afshin tahmasebi
departments of internal medicine, school of medicine and student research committee, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

پیمان متقی | peyman mottaghi
departments of rheumatology, school of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9009
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/218/article-218-330990.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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