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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۰۳، صفحات ۰-۰
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عنوان انگلیسی Therapeutic effects of deferoxamine and silymarin versus deferoxamine alone in β-thalassemia major based on findings of liver MRI
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 BACKGROUND: Thalassemia is an inherited disorder in which repeated blood transfusion is needed. This causes accumulation of iron in various organs. Silymarin is a natural medicinal plant that has been used for centuries in the treatment of liver depositions. In this study, magnetic resonance imaging (MRI) of liver, which has high accuracy in measuring liver iron concentration (LIC), was used to evaluate the effects of silymarin (Legalon) as an iron-chelating agent. METHODS: In this double-blind randomized clinical-trial study, 48 thalassemic patients were enrolled during a period of 6 months. In order to evaluate the efficacy of Legalon on LIC, the control group was treated with deferoxamine and placebo tablets while the case group received a combination of deferoxamine and silymarin. MRI was performed for all patients before and after the intervention to determine liver iron using Gandon's protocol. RESULTS: Overall, 37 patients, including 22 controls and 15 cases, completed the study. The mean concentrations of liver iron at baseline were 290 ± 62 µmol/g and 328 ± 27.8 µmol/g in the control and case groups, respectively. The mean liver iron concentrations after 6 months of intervention were 290.4 ± 65.4 µmol/g and 334.6 ± 27.9 µmol/g in the control and case groups, respectively. No group experienced a significant difference in LIC change before and after the 6-month trial (p = 0.43). CONCLUSIONS: Administration of silymarin did not cause significant changes in liver iron concentration. Evaluating a longer course of treatment with this drug is thus suggested. KEYWORDS: Beta-Thalassemia; Magnetic Resonance Imaging; Silymarin, Deferoxamine
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نویسندگان مقاله آتوسا ادیبی | atousa adibi
associate professor of radiology, department of radiology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

آذین شایگان فر | azin shayganfar
radiologist, department of radiology, school of medicine, isfahan university of medical sciences ,isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

بهجت سادات مویدی | behjat sadat moayedi
professor, department of immunology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مرجان قراگوزلو | marjan gharagozloo
department of immunology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سید محمد جواد مرعشی | seyed mohammad javad maraashi
5 professor, department of radiology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد مراثی | mohammad maracy
associate professor, department of biostatistics and epidemiology, school of public health, isfahan university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

ندا ادیبی | neda adibi
dermatologist, psychosomatic research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8182
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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