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World Journal of Plastic Surgery، جلد ۶، شماره ۲، صفحات ۰-۰
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عنوان انگلیسی The Effect of Grape Seed Oil Enema with or without Sesame Oil in Acetic Acid Induced Ulcerative Colitis of Rats
چکیده انگلیسی مقاله BACKGROUND Inflammatory bowel diseases contain two digestive system diseases, ulcerative colitis (UC) and Crohn’s disease with unclear causes. The aim of present study was to investigate the therapeutic effects of administration of the Sesame oil (SO) and grape seed oil (GSO) as enema route in rats suffering from experimental acetic acid induced UC. METHODS Eighty male rats were randomly allocated into 8 equal groups as health control (HC1) without any disease treated with 1 ml of normal saline as enema; HC2 received SO; HC3 received GSO; negative control (NC) with induced UC receiving 1 ml of normal saline as enema; and positive control (PC) with induced UC treated by asacol. All treatments were performed identically with 4 mg/kg of medication except for asacol that was 100 mg/kg for 7 days. The weight changes was recorded after seven days. The serum levels of malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin-6, and c-reactive protein (CRP) were measured. Colon macroscopic and microscopic histological changes were also measured at the end of 7th day. RESULTS No significant changes were detected in weight in neither groups on day 0 nor at the end of study. No beneficial effects were seen for all treatments regarding healing process and the decrease in inflammation. Between treatment groups, the lowest MDA (7.40±0.98 U/ml), CRP (83.20±10.01 mg/l) and IL-6 levels (130.86±10.70 mU/ml) and highest TAC (1.91±0.43 mmol/l) belonged to GSO group. CONCLUSION GSO enema alone can be considered as a treatment of choice for UC due to its antioxidant properties
کلیدواژه‌های انگلیسی مقاله Grape seed oil, Sesame oil, Ulcerative colitis, Enema
نویسندگان مقاله فاطمه حسین زاده | fatemeh hosseinzadeh
department of clinical nutrition, school of nutrition and food sciences, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

موسی صالحی | moosa salehi
department of clinical nutrition, school of nutrition and food sciences, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نادر تنیده | nader tanideh
stem cell technology research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

داود مهربانی | davood mehrabani
stem cell technology research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

آزاده سیاری فرد | azadeh sayarifard
center for academic and health policy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

آناهیتا صدیقی | anahita sedighi
department of cellular and molecular biology, pharmaceutical science branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://wjps.ir/browse.php?a_code=A-10-243-1&slc_lang=en&sid=en
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