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World Journal of Plastic Surgery، جلد ۶، شماره ۱، صفحات ۲۶-۳۲
عنوان فارسی
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عنوان انگلیسی Effect of Basic Fibroblast Growth Factor on Achilles Tendon Healing in Rabbit
چکیده انگلیسی مقاله BACKGROUND Tendon injuries are common and it takes a long time for an injured tendon to heal. Adverse phenomena such as adhesion and rupture are associated with these injuries. Finding a method to reduce the time required for healing whichimproves the final outcome, will lead to decreased frequency and intensity of adverse consequences. This study was designed to investigate the effects of basic fibroblast growth factor on the healing of the Achilles tendon in rabbits METHODS In 10 New Zealand white rabbits, Achilles tendon was cut at the intersection of the distal and middle thirds on both hind legs. One microgram of recombinant basic fibroblast growth factor (bFGF) was injected in the proximal and distal stumps of the cut tendon on the right side (study group). Normal saline of equal volume was injected on the left side in the same way (control group). Then the tendons were repaired with 5/0 nylon using modified Kessler technique. A cast was made to immobilize each leg. On day 42, rabbits were euthanized and both hind legs were amputated. Tensometry and histopathologic examination were done on specimens. RESULTS In tensometric studies, more force was required to rupture the repair site in study group. In histopathologic examination, collagen fibers had significantly better orientation and organization in the study group. No difference was noted regarding number of fibroblast and fibrocytes, and degree of angiogenesis in the two groups. CONCLUSION Application of basic fibroblast growth factor at tendon repair site improves the healing process through improvement of collagen fiber orientation and increase in biomechanical resistance.
کلیدواژه‌های انگلیسی مقاله Tendon injury, Healing,Fibroblast growth factor,Rabbit
نویسندگان مقاله آرش نجف بیگی | arash najafbeygi
department of plastic surgery, burn research center, hazrate fatemeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد جواد فاطمی | mohammad javad fatemi
department of plastic surgery, burn research center, hazrate fatemeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

امیرحسین لباسچی | amir hussein lebaschi
department of plastic surgery, burn research center, hazrate fatemeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید جابر موسوی | seyed jaber mousavi
department of plastic surgery, burn research center, hazrate fatemeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

دکتر سیدابوذر حسینی | seyed abouzar husseini
department of plastic surgery, burn research center, hazrate fatemeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

میترا نیازی | mitra niazi
department of plastic surgery, burn research center, hazrate fatemeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://wjps.ir/browse.php?a_code=A-10-35-3&slc_lang=en&sid=en
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