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مجله علوم اعصاب شفای خاتم، جلد ۳، شماره ۴، صفحات ۴۱-۴۱
عنوان فارسی P۱۴: Therapeutic Potential of Induced Pluripotent Stem Cells for Spinal Cord Injury
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
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عنوان انگلیسی P14: Therapeutic Potential of Induced Pluripotent Stem Cells for Spinal Cord Injury
چکیده انگلیسی مقاله Spinal cord injury (SCI) is a destructive event that often lead to permanent neurologic deficit. Current clinical treatments are aimed at preventing secondary damage, promoting regeneration, and replacing destroyed spinal cord tissue, although effective treatments for SCI remain limited. Cell therapies for treating SCI are promising therapy for replacing dead cells, neuroprotection and axon regeneration. A number of different pluripotent, multipotent, and differentiating stem cells have been investigated so far for the treatment of SCI. Some of these cells have entered or will soon be entering clinical trials. Basic and pre-clinical experimental studies have highlighted the positive effects of Induced pluripotent stem cells (iPSCs) treatment after spinal cord and peripheral nerve injury. iPSCs are a type of pluripotent stem cell that directly can be generated from adult cells and their therapeutic effects are believed to be due to their potential to differentiate into neural precursor cells, neurons, oligodendrocytes, astrocytes  and neural crest cells that can act by replacing lost cells or providing environmental support. iPSCs can provide a cell source that has characteristics of embryonic stem cells. However, human iPSCs solve the ethical dilemma posed by human embryonic stem cells research. In addition, they can be sourced from autologous sources, which may decrease the risk of immune rejection.
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نویسندگان مقاله سارا عبدالهی | sara abdolahi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. department of biotechnology, school of veterinary science, shiraz university, shiraz, iran

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

مریم برهانی حقیقی | maryam borhani haghighi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. department of anatomy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

هادی علیقلی | hadi aligholi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. department of neuroscience, school of advanced medical sciences and technologies, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-647&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332127.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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