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مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۴، صفحات ۵۰-۵۰
عنوان فارسی W۷: In Vitro Traumatic Brain Injury Models
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
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عنوان انگلیسی W7: In Vitro Traumatic Brain Injury Models
چکیده انگلیسی مقاله Traumatic brain injury (TBI) is caused by rapid deformation of the brain, resulting in a cascade of pathological events and ultimately neurodegeneration. In vitro models of TBI can help us to describe the pathobiological mechanisms. In vitro models of brain injury support a platform for performing repeatable, well-controlled, environmentally isolated experiments. Other advantages of in vitro models of injury are monitoring in real time and evaluation of specific region. Acute preparations, organotypic cultures, dissociated primary cultures, and immortalized cell line have been used to study neural injury in vitro. Several in vitro models of TBI have been designed, they include the following: Transection: in vitro transection models leading to axotomy. Compression: this model of TBI can be induced primary and secondary injury by the impactor. Hydrostatic pressure: using transient or static pressure, deformation is induced. Fluid shear stress: culture cells have been deformed using a fluid shear forces. Shear strain: in vitro shear strain model has been simulated for closed-head TBI. Stretch injury models: in vitro models of Stretch injury have been developed to reproduce the mechanics which occur during in vivo TBI. Using appropriate in vitro models, we can understand mechanisms of injury in details and evaluate the effects of potential treatments.
کلیدواژه‌های انگلیسی مقاله In vitro, TBI, Injury, Pathobiology
نویسندگان مقاله سجاد سحاب نگاه | sajad sahab negah
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. histology and embryology group, basic science department, faculty of veterinary medicine, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

هادی علیقلی | hadi aligholi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

شاهین محمد صادقی | shahin mohammad sadeghi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. department of plastic and reconstructive surgery, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مصطفی مدرس موسوی | mostafa modarres mousavi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-396&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332247.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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