این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۴، صفحات ۹۱-۹۱
عنوان فارسی P۴۱: Therapeutic Effect of Transplanting Neural Stem Cells Derived Bone Marrow Stromal Cells Using Bioactive Substance TNT, for Enhance Recovery from Spinal Cord Injury
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P41: Therapeutic Effect of Transplanting Neural Stem Cells Derived Bone Marrow Stromal Cells Using Bioactive Substance TNT, for Enhance Recovery from Spinal Cord Injury
چکیده انگلیسی مقاله Bone marrow mesenchymal stem cells can differentiate into neurons and astrocytes after transplantation in the spinal cord injury of rats. Although bone marrow mesenchymal stem cells are known to protect against spinal cord injury through anti-apoptotic effects, but generation of neural stem cells with large number and safety protocols unclear. In the present study, described the differentiation of bone marrow stromal cells (BMSC) into a neural stem cell-like under the influence of a factor inducing non-toxic bioactive substance TNT.In the present study, bone marrow mesenchymal stem cells were cultured and proliferated, then induced with bioactive substance TNT. That these cells differentiate as a neurosphere-like structures and neural stem cells. These cells approved by immunocytochemistry and RT-PCR technique. These cells transplanted into rats with spinal cord injury. Immunohistochemistry and immunofluorescence with subsequent quantification revealed that the expression of the axonal regeneration marker and the neuronal marker, microtubule-associated protein 2, significantly increased in rats with bone marrow mesenchymal stem cell transplantation compared with those in rats with spinal cord injury. Our results suggest that bone marrow mesenchymal stem cell transplantation promotes neurite growth and regeneration and prevents autophagy. These responses may likely be mechanisms underlying the protective effect of bone marrow mesenchymal stem cells against spinal cord injury. Transplanting BMSCs can enhance the protein expression of neural growth factor in the rats which undergo injury to their spinal cord. It can be significantly improved the rehabilitation of the motor function. The improvement is associated with the transplantation of BMSCs which are beneficial for regeneration and repair of the rat’s spinal cord injury.
کلیدواژه‌های انگلیسی مقاله BMSC, Spinal Cord Injury, Transplantation, Neural Stem Cells
نویسندگان مقاله پرستو براتی | parastoo barati
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

علیرضا مرادی | alireza moradi
department of physiology, islamic azad university of qom, qom, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مرضیه درویشی | marzieh darvishi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

تقی طریحی | taghi tiraihi
department of anatomy, tarbiat modares university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-437&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332288.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات