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مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۴، صفحات ۹۶-۹۶
عنوان فارسی P۴۶: Therapeutic Potential of Neural Stem Cells for Spinal Cord Injury
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P46: Therapeutic Potential of Neural Stem Cells for Spinal Cord Injury
چکیده انگلیسی مقاله Spinal cord injury (SCI) is a destructive condition that the cord can't send signals below the level of the injury. Despite advances in the medical and surgical care of SCI patients, no effective treatment exists for the neurological deficits of SCI. Cell therapy is a new approach for SCI, and preclinical models demonstrate that cell transplantation can improve some secondary events through neuroprotection and also restore lost tissue through regeneration. Neural Stem Cells (NSCs) are multipotent cells committed to the neural lineage that can self-renew. NSCs are found in both fetal and adult central nervous system (CNS). NSCs locate within specific niches in the adult CNS, including the subventricular zone in the lateral ventricles of the forebrain, the dentate gyrus of the hippocampus, olfactory bulb and the region of the central canal of the spinal cord. Transplantation of NSCs into injured tissue, promoted functional recovery with neuroprotective and neuroregenerative effects. Most studies with transplanted NSCs have shown modest recovery of the injured spinal cord. Adult mouse brain–derived NSCs transplanted into the injured rat spinal cord with concomitant infusion of growth factors promoted oligodendrocyte differentiation of the grafted NSCs, remyelination, and improved locomotor function. NSCs derived from fetal rat spinal cord differentiated into neurons that integrated into the injured cord and improved recovery, and transplanted NSCs combined with valproic acid administration promoted neuronal differentiation, resulting in restoration of disrupted neuronal circuitry and enhanced recovery. NSCs have also demonstrated some immunomodulatory and pathotropic ability by homing toward damaged tissue as well as secreting various neurotrophic factors and cytokines. Neuralstem cells also express nerve growth factors that are essential to the healthy function of the CNS. These could protect the patient’s own neurons from further degeneration due to injury. By solving some limitations in future, cell therapy can open a new window for treatment of SCI.
کلیدواژه‌های انگلیسی مقاله Neural Stem Cells, Spinal Cord Injury, Cell Therapy
نویسندگان مقاله سجاد سحاب نگاه | sajad sahab negah
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. histology and embryology group, basic science department, veterinary medicine faculty, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

هادی علیقلی | hadi aligholi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

مصطفی مدرس موسوی | mostafa modarres mousavi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

ذبیح اله خاکسار | zabihollah khaksar
histology and embryology group, basic science department, veterinary medicine faculty, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

هادی کاظمی | hadi kazemi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. pediatric department, shahed university, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

شاهین محمد صادقی | shahin mohammad sadeghi
department of plastic and reconstructive surgery, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-443&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332293.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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